Bradycardia during Induction Therapy with All-trans Retinoic Acid in Patients with Acute Promyelocytic Leukemia: Case Report and Literature Review
المؤلفون المشاركون
Chen, Pin-Zi
Wu, Yee-Jen
Wu, Chien-Chih
Wang, Yu-Wen
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-07
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
A 41-year-old man with newly diagnosed acute promyelocytic leukemia (APL) received induction chemotherapy, containing all-trans retinoic acid (ATRA), idarubicin, and arsenic trioxide.
On the 11th day of therapy, he experienced complete atrioventricular (AV) block; therefore, ATRA and arsenic trioxide were immediately postponed.
His heart rate partially recovered, and ATRA was rechallenged with a half dose.
However, complete AV block as well as differentiation syndrome recurred on the next day.
ATRA was immediately discontinued, and a temporary pacemaker was inserted.
Two days after discontinuing ATRA, AV block gradually improved, and ATRA was uneventfully rechallenged again.
The Naranjo adverse drug reaction probability scale was 7 for ATRA, suggesting it was the probable cause of arrhythmia.
A literature search identified 6 other cases of bradycardia during ATRA therapy, and all of them occurred during APL induction therapy, with onset ranging from 4 days to 25 days.
Therefore, monitoring vital signs and performing electrocardiogram are highly recommended during the first month of induction therapy with ATRA.
ATRA should be discontinued if complete AV block occurs.
Rechallenging with ATRA can be considered in fully recovered and clinically stable patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Pin-Zi& Wu, Yee-Jen& Wu, Chien-Chih& Wang, Yu-Wen. 2018. Bradycardia during Induction Therapy with All-trans Retinoic Acid in Patients with Acute Promyelocytic Leukemia: Case Report and Literature Review. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1143869
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Pin-Zi…[et al.]. Bradycardia during Induction Therapy with All-trans Retinoic Acid in Patients with Acute Promyelocytic Leukemia: Case Report and Literature Review. Case Reports in Hematology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1143869
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Pin-Zi& Wu, Yee-Jen& Wu, Chien-Chih& Wang, Yu-Wen. Bradycardia during Induction Therapy with All-trans Retinoic Acid in Patients with Acute Promyelocytic Leukemia: Case Report and Literature Review. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1143869
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1143869
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر