Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome Associated with Deletion of Chromosome 20q
المؤلفون المشاركون
Manthri, Sukesh
Vasireddy, Naresh K.
Bandaru, Sindhura
Pathak, Swati
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-01
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Elliptocytosis is commonly seen as a hereditary condition.
We present a case of myelodysplastic syndrome (MDS) del(q20) variant with concomitant acquired elliptocytosis.
A 73-year-old male with a history of prostate cancer presented to the hospital for evaluation of bleeding gums.
Initial evaluation showed Hgb of 9.3 gm/dl, hematocrit of 28%, platelet count of 36,000 K/cmm, and WBC of 1.8 K/cmm with an ANC of 0.8 K/cmm.
A slightly elevated bilirubin of 1.2 mg/dl spurred a hemolytic workup.
Peripheral smear showed frequent elliptocytes, teardrop cells, schistocytes, and occasional spherocytes.
Bone marrow biopsy did not show significant fibrosis to explain the elliptocytosis.
Cytogenetics showed 20q deletion, and later, he was started on therapy for intermediate risk MDS.
Bone marrow biopsy after completion of 6 cycles showed complete cytogenetic remission with significant improvement in elliptocytosis.
Elliptocytosis in the setting of MDS has rarely been reported, and association with 20q deletion is even rarer.
Animal studies have shown that haploinsufficiency of L3MBTL1 contributes to some (20q−) myeloproliferative neoplasms and myelodysplastic syndromes by affecting erythroid differentiation.
Our case report raises interesting questions: Does MDS with rarely reported elliptocytosis indicate a disease process that is different from the usual 20q deletion? Is haploinsufficiency of L3MBTL1 responsible for this manifestation?
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Manthri, Sukesh& Vasireddy, Naresh K.& Bandaru, Sindhura& Pathak, Swati. 2018. Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome Associated with Deletion of Chromosome 20q. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1143958
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Manthri, Sukesh…[et al.]. Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome Associated with Deletion of Chromosome 20q. Case Reports in Hematology No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1143958
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Manthri, Sukesh& Vasireddy, Naresh K.& Bandaru, Sindhura& Pathak, Swati. Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome Associated with Deletion of Chromosome 20q. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1143958
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1143958
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر