Drug-Induced Thrombotic Microangiopathy due to Cumulative Toxicity of Ixazomib

المؤلفون المشاركون

Atallah-Yunes, Suheil Albert
Soe, Myat Han

المصدر

Case Reports in Hematology

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-07-03

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأمراض

الملخص EN

Drug-induced thrombotic microangiopathies (DTMAs) are increasingly being recognized as an important category of thrombotic microangiopathies (TMAs).

Cancer therapeutic agents including proteasome inhibitors (PIs) are among the most common medications reported to cause DTMA.

PIs could cause DTMA either by an immune mechanism or dose-dependent/cumulative toxicity.

Eleven cases of DTMA have been reported with bortezomib and carfilzomib.

To the best of our knowledge, only one case of DTMA has been reported with ixazomib due to an immune-mediated mechanism.

Here, we report the first case of ixazomib-induced DTMA due to cumulative toxicity rather than immune-mediated mechanism.

In this article, we discuss the precipitating factors for cumulative toxicity of ixazomib, resulting in DTMA, diagnostic workup, and management of DTMA.

We also discuss clinical reasoning based analysis of DTMA versus cancer-associated TMA as well as DTMA versus cyclic thrombocytopenia seen in PI use.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Atallah-Yunes, Suheil Albert& Soe, Myat Han. 2018. Drug-Induced Thrombotic Microangiopathy due to Cumulative Toxicity of Ixazomib. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1143975

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Atallah-Yunes, Suheil Albert& Soe, Myat Han. Drug-Induced Thrombotic Microangiopathy due to Cumulative Toxicity of Ixazomib. Case Reports in Hematology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1143975

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Atallah-Yunes, Suheil Albert& Soe, Myat Han. Drug-Induced Thrombotic Microangiopathy due to Cumulative Toxicity of Ixazomib. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1143975

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1143975