Severe and Fatal Multilobar Nonclassic Radiation Pneumonitis following Stereotactic Body Radiation Therapy (SBRT) for Treatment of Inoperable Non-Small-Cell Lung Cancer: A Report of Two Cases and Possible Enhancement by Concurrent Amiodarone
المؤلفون المشاركون
Georgiou, Anastasios
Farmer, Adam
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Stereotactic body radiation therapy (SBRT) is considered the standard of care for treatment of inoperable early stage non-small cell carcinoma of the lung.
SBRT delivers a very high dose of ionizing radiation to a relatively small region encompassing the tumor and spares a significant portion of the remaining lung from high doses.
However, the conformal high dose comes at the expense of treating a larger volume of normal lung to lower doses.
In general, this has been deemed to be acceptable with an overall lower risk of radiation pneumonitis.
However, in the face of predisposing factors, the higher doses delivered by this technique may lead to an increase in radiation pneumonitis.
We report on two patients being treated with SBRT in which severe radiation pneumonitis developed in spite of our radiation dosimetry being significantly below the acceptable limit for lung toxicity.
Both patients developed a “fulminant” form of radiation pneumonitis with radiographic abnormalities well beyond the treated volume.
In one patient, the disease proved fatal.
Both patients were on amiodarone at the time SBRT was administered.
Given the rarity of fulminant radiation pneumonitis, especially with the relatively small fields treated by SBRT, we suspect that amiodarone enhanced the pulmonary toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Georgiou, Anastasios& Farmer, Adam. 2019. Severe and Fatal Multilobar Nonclassic Radiation Pneumonitis following Stereotactic Body Radiation Therapy (SBRT) for Treatment of Inoperable Non-Small-Cell Lung Cancer: A Report of Two Cases and Possible Enhancement by Concurrent Amiodarone. Case Reports in Pulmonology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1143978
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Georgiou, Anastasios& Farmer, Adam. Severe and Fatal Multilobar Nonclassic Radiation Pneumonitis following Stereotactic Body Radiation Therapy (SBRT) for Treatment of Inoperable Non-Small-Cell Lung Cancer: A Report of Two Cases and Possible Enhancement by Concurrent Amiodarone. Case Reports in Pulmonology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1143978
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Georgiou, Anastasios& Farmer, Adam. Severe and Fatal Multilobar Nonclassic Radiation Pneumonitis following Stereotactic Body Radiation Therapy (SBRT) for Treatment of Inoperable Non-Small-Cell Lung Cancer: A Report of Two Cases and Possible Enhancement by Concurrent Amiodarone. Case Reports in Pulmonology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1143978
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1143978
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر