Acute Lymphoblastic Leukemia following Lenalidomide Maintenance for Multiple Myeloma: Two Cases with Unexpected Presentation and Good Prognostic Features
المؤلفون المشاركون
Khan, Abdullah M.
Muzaffar, Jameel
Murthy, Hemant
Wingard, John R.
Moreb, Jan S.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-12
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Lenalidomide maintenance following autologous stem cell transplant (ASCT) is considered the standard of care for eligible patients with multiple myeloma (MM).
A recent meta-analysis has provided additional evidence that lenalidomide maintenance is associated with a higher incidence of second primary malignancies, including both hematologic and solid malignancies.
Acute lymphoblastic leukemia (ALL) as a second primary malignancy is rarely described in the literature.
Herein, we describe two patients with MM treated with induction therapy, ASCT, and lenalidomide maintenance that experienced cytopenias while on maintenance.
ALL was unexpectedly diagnosed on bone marrow biopsy.
One patient was diagnosed on routine biopsy performed as part of requirements of the clinical trial.
Both patients had B-cell ALL, without known poor risk cytogenetics, and were managed with standard induction therapies resulting in complete remission.
We also reviewed the literature for similar cases of secondary ALL (sALL) in MM patients exposed to immunomodulatory drugs (IMiDs).
In conclusion, persistent cytopenias in responding MM patients receiving IMiDs maintenance should be an indication for bone marrow biopsy.
Patients develop sALL after median of 32.5 months (range, 20–84) from being on lenalidomide or thalidomide maintenance, often presenting with cytopenias, display low tolerance to chemotherapy, but remission can often be achieved.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khan, Abdullah M.& Muzaffar, Jameel& Murthy, Hemant& Wingard, John R.& Moreb, Jan S.. 2018. Acute Lymphoblastic Leukemia following Lenalidomide Maintenance for Multiple Myeloma: Two Cases with Unexpected Presentation and Good Prognostic Features. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1144089
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khan, Abdullah M.…[et al.]. Acute Lymphoblastic Leukemia following Lenalidomide Maintenance for Multiple Myeloma: Two Cases with Unexpected Presentation and Good Prognostic Features. Case Reports in Hematology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1144089
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khan, Abdullah M.& Muzaffar, Jameel& Murthy, Hemant& Wingard, John R.& Moreb, Jan S.. Acute Lymphoblastic Leukemia following Lenalidomide Maintenance for Multiple Myeloma: Two Cases with Unexpected Presentation and Good Prognostic Features. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1144089
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1144089
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر