![](/images/graphics-bg.png)
Sorafenib-Associated Heart Failure Complicated by Cardiogenic Shock after Treatment of Advanced Stage Hepatocellular Carcinoma: A Clinical Case Discussion
المؤلفون المشاركون
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Sorafenib, an oral tyrosine kinase inhibitor (TKI), targets multiple tyrosine kinase receptors (TKRs) involved in angiogenesis and tumor growth.
Studies suggest that inhibition of TKR impacts cardiomyocyte survival.
Inhibition of VEGF signaling interrupts angiogenesis and is associated with the development of hypertension and compensatory hypertrophy.
Compensated hypertrophy ultimately leads to heart failure.
Case Description.
A 76-year-old man with a past medical history of systolic heart failure due to ischemic cardiomyopathy and stage IIIC hepatocellular carcinoma (HCC) presented with symptoms of decompensated heart failure.
Four months prior to admission, he was started on sorafenib.
Results.
Our patient was treated with intravenous furosemide and guideline directed therapy.
Clinical status was complicated by the development of low cardiac output and shock requiring inotropic support.
Careful titration of heart failure medication led to hemodynamic improvement and discontinuation of dobutamine.
Conclusion.
Greater awareness of sorafenib cardiotoxicity is essential.
As TKI usage grows for treatment of cancers, heart failure-related complications will increase.
In our patient, routine heart failure management and cessation of sorafenib led to clinical improvement.
Future studies on the treatment of sorafenib cardiotoxicity should be explored further in this unique patient population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Candace& Shemisa, Kamal. 2017. Sorafenib-Associated Heart Failure Complicated by Cardiogenic Shock after Treatment of Advanced Stage Hepatocellular Carcinoma: A Clinical Case Discussion. Case Reports in Cardiology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1144150
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Candace& Shemisa, Kamal. Sorafenib-Associated Heart Failure Complicated by Cardiogenic Shock after Treatment of Advanced Stage Hepatocellular Carcinoma: A Clinical Case Discussion. Case Reports in Cardiology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1144150
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Candace& Shemisa, Kamal. Sorafenib-Associated Heart Failure Complicated by Cardiogenic Shock after Treatment of Advanced Stage Hepatocellular Carcinoma: A Clinical Case Discussion. Case Reports in Cardiology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1144150
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1144150
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)