Papillary Fibroelastoma as a Cause of Cardiogenic Embolic Stroke in a β-Thalassemia Patient: Case Report and Literature Review

الملخص EN

We describe a case of a young male without stroke risk factors who presented with a sudden onset of left-sided weakness, left hand numbness, and left eye blurriness.

CT scan of the head without contrast and diffusion-weighted MRI of the brain with contrast revealed an ischemic stroke in the right middle cerebral artery distribution.

Transesophageal echocardiography (TEE) revealed a mobile pedunculated mass on the posterior surface of the mitral valve.

This mass was resected and pathology showed a cardiac papillary fibroelastoma (CPFE), which was determined to be the cause of the patient’s cardioembolic stroke.

Further workup also found that patient had microcytic anemia secondary to β-thalassemia intermedia, a rare hematologic disorder due to defective hemoglobin synthesis.

Recently, another case report suggested β-thalassemia major may underlie the pathogenesis of CPFE.

β-Thalassemia major causes a state of chronic inflammation and endothelial damage, which can mediate CPFE formation.

Based on literature review, this is the first case report of a CPFE in a patient with β-thalassemia intermedia.

This hypothesis-generating case report calls attention to the need for elucidating the relationship between CPFE and β-thalassemia in future studies to better understand the diagnosis and management of a rare cardiac tumor.