Urinary Catheter Colonization by Multidrug-Resistant Cedecea neteri in Patient with Benign Prostatic Hyperplasia

الملخص EN

Cedecea neteri, a member of the Enterobacteriaceae family, has only been identified as a human pathogen in a few previous clinical cases, thus complicating assessment of this organism’s pathogenicity and medical relevance.

Documented infections attributed to C.

neteri primarily involved bacteremia in severely immunocompromised patients.

We report a rare case of urinary catheter colonization by a multidrug-resistant C.

neteri strain in a patient of advanced age with benign prostatic hyperplasia and other chronic comorbidities.

This C.

neteri isolate was resistant or intermediate to second-generation cephalosporins, penicillins, and certain β-lactamase inhibitor/β-lactam combinations.

Analysis of whole genome sequence information for a representative C.

neteri strain indicated the presence of multiple open reading frames with sequence similarity to β-lactamases, including a chromosome-encoded AmpC β-lactamase and metallo-β-lactamases, consistent with the resistance phenotype of this bacterium.

The presence of an AmpR homolog suggests that the C.

neteri ampC may be inducible in response to β-lactam exposure.

Molecular insights into antibiotic resistance traits of this emerging opportunistic pathogen will be important for administering adequate antibiotic treatment to ensure favorable patient outcomes.