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Chronic Myeloid Leukemia and Cesarean Section: The Anesthesiologist’s Point of View
المؤلفون المشاركون
El Adib, Ahmed Ghassan
Rebahi, Houssam
Ait Sliman, Mourad
المصدر
Case Reports in Obstetrics and Gynecology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-18
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Background.
Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm related to chromosomal reciprocal translocation t(9;22).
Tyrosine kinase inhibitors (TKIs) such as imatinib have drastically revolutionized the course and the prognosis of this hematologic malignancy.
As we know, the association pregnancy-CML is an infrequent situation.
Also the use of TKI in pregnant women is unsafe with a lack of alternatives and effective therapeutic options.
Thus its cessation during gestation puts those patients at high risk of developing blast crisis characterized by poor outcomes.
Case Report.
A 37-year-old pregnant woman, gravida 2, para 2, with a previous cesarean section in 2011, presented to the obstetric unit.
Her medical past revealed that she is a newly diagnosed patient with CML managed by TKI during her preconception period.
Due to the perilous use of TKI during her pregnancy, a switch to interferon-α administration was adopted.
But after the completion of 36 weeks of gestation, disease progression (relapse with blast crisis), attested by biological worsening, a white blood cell count = 245000/mm3 with 32% blasts in the peripheral blood, urged the medical team to opt for cesarean delivery.
She underwent general endotracheal anesthesia without any perioperative incidents and gave birth to a healthy newborn.
Ten days later, the patient was started on TKI.
Discussion.
Although data on this specific and challenging situation are limited, this case highlights the difficulties encountered by the anesthesiologists when choosing the accurate anesthetic strategy and how important it is to weigh the risks and benefits inherent to each technique.
Above all, taking into consideration the possible central nervous system (CNS) contamination by circulating blast cells when performing spinal or epidural approach is primordial.
This potential adverse event (CNS blast crisis) is extremely scarce but it is responsible for high rates of morbidity and mortality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rebahi, Houssam& Ait Sliman, Mourad& El Adib, Ahmed Ghassan. 2018. Chronic Myeloid Leukemia and Cesarean Section: The Anesthesiologist’s Point of View. Case Reports in Obstetrics and Gynecology،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1145679
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rebahi, Houssam…[et al.]. Chronic Myeloid Leukemia and Cesarean Section: The Anesthesiologist’s Point of View. Case Reports in Obstetrics and Gynecology No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1145679
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rebahi, Houssam& Ait Sliman, Mourad& El Adib, Ahmed Ghassan. Chronic Myeloid Leukemia and Cesarean Section: The Anesthesiologist’s Point of View. Case Reports in Obstetrics and Gynecology. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1145679
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1145679
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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