Risk Factors and Changes of Peripheral NK and T Cells in Pulmonary Interstitial Fibrosis of Patients with Rheumatoid Arthritis
المؤلفون المشاركون
Li, Xiaofeng
Lai, Na-Lin
Jia, Wen
Wang, Xia
Liu, Guang-Ying
Gao, Chong
Xie, Jian-Fang
Luo, Jing
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-01
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
The absolute and relative changes of peripheral NK and T subsets are unclear in rheumatoid arthritis (RA) associated with pulmonary interstitial fibrosis (RA-ILD).
To investigate the clinical risk factors, especially the changes of lymphocyte subsets, in RA-ILD in order to make early diagnosis and achieve prevention of the pulmonary interstitial lesions.
Methods.
A total of 100 RA and 100 RA-ILD patients were enrolled.
Rheumatoid factor, anti-cyclic citrulline peptide antibody, erythrocyte sedimentation rate, immunoglobulin, and C-reactive protein were examined.
The percentage and absolute number of NK, T, B, Treg, Th1, Th2, and Th17 cells in peripheral blood were determined by flow cytometry.
Results.
RA-ILD is more common in older and male RA patients and/or those with higher autoantibody titers.
Flow cytometry showed that the absolute and relative numbers of CD56+ NK cells were significantly higher in RA-ILD (280.40 ± 180.51 cells/μl vs.
207.66 ± 148.57 cells/μl; 16.62 ± 8.56% vs.
12.11 ± 6.47%), whereas the proportion of T cells and CD4+ T cells was lower in peripheral blood of RA-ILD patients (69.82 ± 9.30%; 39.44 ± 9.87 cells/μl) than that in RA patients (74.45 ± 8.72%; 43.29 ± 9.10 cells/μl).
Conclusions.
The occurrence of RA-ILD is closely related to the older male patients with high titer of various self-antibodies.
Imbalance of CD3−CD56+ NK cells and T cells with other subsets were found in RA-ILD patients, which, together with older age, male, and high levels of autoantibodies should be considered as risk factors of pulmonary interstitial lesions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lai, Na-Lin& Jia, Wen& Wang, Xia& Luo, Jing& Liu, Guang-Ying& Gao, Chong…[et al.]. 2019. Risk Factors and Changes of Peripheral NK and T Cells in Pulmonary Interstitial Fibrosis of Patients with Rheumatoid Arthritis. Canadian Respiratory Journal،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1145789
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lai, Na-Lin…[et al.]. Risk Factors and Changes of Peripheral NK and T Cells in Pulmonary Interstitial Fibrosis of Patients with Rheumatoid Arthritis. Canadian Respiratory Journal No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1145789
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lai, Na-Lin& Jia, Wen& Wang, Xia& Luo, Jing& Liu, Guang-Ying& Gao, Chong…[et al.]. Risk Factors and Changes of Peripheral NK and T Cells in Pulmonary Interstitial Fibrosis of Patients with Rheumatoid Arthritis. Canadian Respiratory Journal. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1145789
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1145789
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر