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High-Grade B-Cell Neoplasm with Surface Light Chain Restriction and Tdt Coexpression Evolved in a MYC-Rearranged Diffuse Large B-Cell Lymphoma: A Dilemma in Classification
المؤلفون المشاركون
Soliman, Dina Sameh
Al-Sabbagh, Ahmad
Ibrahim, Feryal
Yassin, Mohamed
Taha, Ruba Y.
Nawaz, Zafar
Elkourashy, Sarah
Haider, Abdulrazzaq
Akiki, Susanna
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
According to World Health Organization (WHO) classification (2008), B-cell neoplasms are classified into precursor B-cell or a mature B-cell phenotype and this classification was also kept in the latest WHO revision (2016).
We are reporting a male patient in his fifties, with tonsillar swelling diagnosed as diffuse large B-cell lymphoma (DLBCL), germinal center.
He received 6 cycles of RCHOP and showed complete metabolic response.
Two months later, he presented with severe CNS symptoms.
Flow cytometry on bone marrow (BM) showed infiltration by CD10-positive Kappa-restricted B-cells with loss of CD20 and CD19, and downregulation of CD79b.
Moreover, the malignant population showed Tdt expression.
BM Cytogenetics revealed t(8;14)(q24;q32) within a complex karyotype.
Retrospectively, MYC and Tdt immunostains performed on original diagnostic tissue and came negative for Tdt and positive for MYC.
It has been rarely reported that mature B-cell neoplasms present with features of immaturity; however the significance of Tdt acquisition during disease course was not addressed before.
What is unique in this case is that the emerging disease has acquired an immaturity marker while retaining some features of the original mature clone.
No definitive WHO category would adopt high-grade neoplasms that exhibit significant overlapping features between mature and immature phenotypes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Soliman, Dina Sameh& Al-Sabbagh, Ahmad& Ibrahim, Feryal& Taha, Ruba Y.& Nawaz, Zafar& Elkourashy, Sarah…[et al.]. 2017. High-Grade B-Cell Neoplasm with Surface Light Chain Restriction and Tdt Coexpression Evolved in a MYC-Rearranged Diffuse Large B-Cell Lymphoma: A Dilemma in Classification. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1145934
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Soliman, Dina Sameh…[et al.]. High-Grade B-Cell Neoplasm with Surface Light Chain Restriction and Tdt Coexpression Evolved in a MYC-Rearranged Diffuse Large B-Cell Lymphoma: A Dilemma in Classification. Case Reports in Hematology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1145934
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Soliman, Dina Sameh& Al-Sabbagh, Ahmad& Ibrahim, Feryal& Taha, Ruba Y.& Nawaz, Zafar& Elkourashy, Sarah…[et al.]. High-Grade B-Cell Neoplasm with Surface Light Chain Restriction and Tdt Coexpression Evolved in a MYC-Rearranged Diffuse Large B-Cell Lymphoma: A Dilemma in Classification. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1145934
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1145934
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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