Effects of Trimetazidine Pretreatment on Endothelial Dysfunction and Myocardial Injury in Unstable Angina Patients Undergoing Percutaneous Coronary Intervention
المؤلفون المشاركون
Tse, Gary
Li, Guangping
Shao, Shuai
Liu, Tong
Shi, Zhaozhao
Wang, Xinghua
Ni, Yanping
Liu, Hongmei
المصدر
Cardiology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
Trimetazidine is an anti-ischemic medication licensed for the treatment of angina pectoris.
However, the molecular mechanisms underlying its action remain incompletely elucidated.
In this study, therefore, we examined the potential beneficial effects of trimetazidine on myocardial injury and endothelial dysfunction in patients with unstable angina in the perioperative period of percutaneous coronary intervention (PCI).
Methods.
A total of 97 patients with unstable angina were randomly divided into trimetazidine (n = 48) and control (n = 49) groups.
All subjects received standard medical therapy.
The trimetazidine group additionally received 20 mg trimetazidine three times daily 24 hours before and after PCI.
Serum levels of creatine kinase-muscle/brain (CK-MB), cardiac troponin I (cTnI), heart-type fatty acid-binding protein (h-FABP), von Willebrand factor (vWF), and nitric oxide (NO) were measured before and the morning following PCI.
Results.
In the control group, levels of CK-MB, cTnI, and vWF were significantly elevated (P<0.05) and NO level was decreased after PCI (P<0.05).
By contrast, no significant changes in the levels of these proteins were observed in the trimetazidine group after PCI (P>0.05).
Moreover, h-FABP levels were not significantly altered after PCI whether in the control or in the trimetazidine group (P>0.05).
Finally, a time-dependent increase in the levels of h-FABP from 0 to 6 hours after PCI, followed by a progressive decline, was observed (P<0.05).
Conclusions.
PCI induces endothelial dysfunction and myocardial damage in patients with unstable angina.
Trimetazidine therapy in the perioperative period can reduce this damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shao, Shuai& Shi, Zhaozhao& Tse, Gary& Wang, Xinghua& Ni, Yanping& Liu, Hongmei…[et al.]. 2019. Effects of Trimetazidine Pretreatment on Endothelial Dysfunction and Myocardial Injury in Unstable Angina Patients Undergoing Percutaneous Coronary Intervention. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1145957
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shao, Shuai…[et al.]. Effects of Trimetazidine Pretreatment on Endothelial Dysfunction and Myocardial Injury in Unstable Angina Patients Undergoing Percutaneous Coronary Intervention. Cardiology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1145957
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shao, Shuai& Shi, Zhaozhao& Tse, Gary& Wang, Xinghua& Ni, Yanping& Liu, Hongmei…[et al.]. Effects of Trimetazidine Pretreatment on Endothelial Dysfunction and Myocardial Injury in Unstable Angina Patients Undergoing Percutaneous Coronary Intervention. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1145957
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1145957
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر