![](/images/graphics-bg.png)
Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction
المؤلفون المشاركون
Guo, Hai-dong
Shao, Shui-jin
Luo, Zhi-rong
Li, Han
Xiao, Zhong-xin
Zhao, Tian-tian
Zhao, Yue
Mou, Fang-fang
Yu, Bo
المصدر
Cardiology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-10
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Cardiovascular disease has been established as a major cause of morbidity and mortality worldwide, resulting in a huge burden to patients, families, and society.
Traditional Chinese Medicine (TCM) presents several advantages for the prevention and treatment of cardiovascular diseases including multitargets, multi-ingredients, fewer side effects, and low cost.
In this study, a rat model of myocardial infarction (MI) was established by ligating the anterior descending branch of the left coronary artery, and the effect of the Taohong Siwu decoction (THSWD) on cardiac function was evaluated in MI rats.
Following the intragastric administration of THSWD, the cardiac function was examined using echocardiography.
The infarct size and collagen deposition in the infarct area were measured using Masson’s trichrome staining, and the number of CD31- and α-SMA-positive blood vessels in the peri-infarct and infarct area was evaluated by immunofluorescent staining.
The mRNA expression of bFGF, IGF-1, and HGF was detected using RT-PCR assay.
Cell apoptosis in the infarcted area was assessed by TUNEL staining, and the p-Akt level was detected using the western blot assay.
The mitochondrial ROS production was measured using MitoSOX staining, and mitochondrial dynamics and mitophagy were evaluated with western blotting 7 days after THSWD treatment.
THSWD increased the ejection fraction (EF) and fractional shortening (FS) values in the rat hearts; however, no statistical difference was found between the THSWD and MI groups 4 weeks after treatment.
Furthermore, THSWD significantly decreased the value of the left ventricular end-systolic volume (LVESV).
Compared with the model group, THSWD significantly increased the expression of IGF-1 and bFGF, reduced collagen deposition, promoted angiogenesis, reduced cell apoptosis, and activated the PI3K/Akt signaling pathway.
Notably, THSWD significantly decreased mitochondrial ROS production and Fis1 expression.
No statistical differences were observed in the expression of mitochondrial LC3B and Mfn1 between the THSWD and control groups.
In summary, THSWD may possess a beneficial effect on cardiac function by improving the local ischemic microenvironment and by decreasing mitochondrial fission after MI.
Hence, this may present a promising auxiliary strategy in the treatment of ischemic cardiomyopathy such as MI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luo, Zhi-rong& Li, Han& Xiao, Zhong-xin& Shao, Shui-jin& Zhao, Tian-tian& Zhao, Yue…[et al.]. 2019. Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1146006
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luo, Zhi-rong…[et al.]. Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction. Cardiology Research and Practice No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1146006
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luo, Zhi-rong& Li, Han& Xiao, Zhong-xin& Shao, Shui-jin& Zhao, Tian-tian& Zhao, Yue…[et al.]. Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1146006
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146006
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)