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Non-HDL-cTC: A Novel Lipid-Related Marker in the Assessment of Severity of Coronary Artery Lesions and Cardiovascular Outcomes
المؤلفون المشاركون
Qi, Xin
Huang, Anan
Wei, Liping
Zhang, Mingyin
Zhou, Shiqi
المصدر
Cardiology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Non-high-density lipoprotein cholesterol (non-HDL-c) predicts the severity of coronary artery lesions in patients not treated with statin.
The association between non-HDL-c and severity of coronary artery lesions in patients treated with lipid-lowering therapy has been unknown.
Hypothesis.
We hypothesize a novel marker of non-HDL-c/TC predicts the severity of coronary artery lesions and clinical outcomes in 12 months in the patients treated with statin.
Method.
473 subjects who met inclusion criteria were eligible for inclusion.
Coronary artery angiography (CAG) was performed, and the Gensini score (GS) was calculated in all the subjects divided into three subgroups of low risk, medium risk, and high risk by the tertiles of GS.
The non-HDL-c value was calculated as TC minus HDL-c, while non-HDL-c/TC was the ratio of non-HDL-c and TC.
Results.
The concentration of non-LDL-c differed between non-obstructive-CAD group and obstructive-CAD group (P<0.05), and non-HDL-c/TC was elevated in the obstructive-CAD group (P<0.05).
Increased GS was associated with increasing non-HDL-c/TC (P<0.05).
Non-HDL-c/TC (OR: 108.50, 95% CI: 1.57–7520.28; P=0.030) remained as an independent predicting factor of high risk under GS stratification.
In unadjusted Cox model, high non-HDL-c/TC (RR: 1.976, 95% CI: 1.155–3.382; P=0.013) predicted the occurrence of adverse events.
After multivariate adjustment, high non-HDL-c/TC (RR: 1.921, 95% CI: 1.105–3.339; P=0.021) was an independent predictor of poor outcomes.
Conclusion.
High level of non-HDL-c/TC presented an excellent prognostic value compared with other lipid-related markers in CAD patients treated with statin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Anan& Qi, Xin& Wei, Liping& Zhang, Mingyin& Zhou, Shiqi. 2019. Non-HDL-cTC: A Novel Lipid-Related Marker in the Assessment of Severity of Coronary Artery Lesions and Cardiovascular Outcomes. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146018
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Anan…[et al.]. Non-HDL-cTC: A Novel Lipid-Related Marker in the Assessment of Severity of Coronary Artery Lesions and Cardiovascular Outcomes. Cardiology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1146018
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Anan& Qi, Xin& Wei, Liping& Zhang, Mingyin& Zhou, Shiqi. Non-HDL-cTC: A Novel Lipid-Related Marker in the Assessment of Severity of Coronary Artery Lesions and Cardiovascular Outcomes. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146018
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146018
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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