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A Child as a Donor for Hematopoietic Stem Cell Transplantation: Bioethical Justification—A Case Study on Sickle Cell Disease
المؤلفون المشاركون
Hamerschlak, N.
Pereira, Andrea Z.
Hellman, Ricardo
Kondo, Andrea
Souza, Polianna Mara Rodrigues de
Pedreira, Wilson Leite
Mantovani, Luiz Fernando Alves Lima
Troster, Eduardo Juan
Grunspun, Henrique
Bueno, Marco Aurélio Scarpinella
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-23
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Hematopoietic stem cell transplantation (HSCT) is an important treatment option for children with severe and refractory sickle cell disease (SCD) with debilitating clinical complications.
HSCT with cells from the bone marrow of a HLA-identical sibling used in SCD has a low mortality risk, high cure rate, and high event-free survival rate after a median follow-up of 5-6 years.
However, matched donors are found in only about 20% of the patients.
A boy aged 8 years with SCD had a sister, <2 years old, a fully compatible donor.
The boy met all eligibility criteria to undergo HSCT, and he was suffering from cognitive and neurologic impairment due to ischemic events.
A Bioethical Committee jointly discussed the ethical issues on this case after a pediatric evaluation released the very young sister for donation.
The justification was that the sister would benefit from the donation too because of the greater likelihood of survival and cure and less suffering of her brother.
The parents were informed about the risks and benefits for both children, and the family was psychologically evaluated.
After their consent, HSCT was performed and the patient is cured from SCD.
The complication for the donor was the need for blood transfusion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pereira, Andrea Z.& Hellman, Ricardo& Hamerschlak, N.& Kondo, Andrea& Souza, Polianna Mara Rodrigues de& Pedreira, Wilson Leite…[et al.]. 2017. A Child as a Donor for Hematopoietic Stem Cell Transplantation: Bioethical Justification—A Case Study on Sickle Cell Disease. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146023
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pereira, Andrea Z.…[et al.]. A Child as a Donor for Hematopoietic Stem Cell Transplantation: Bioethical Justification—A Case Study on Sickle Cell Disease. Case Reports in Hematology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1146023
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pereira, Andrea Z.& Hellman, Ricardo& Hamerschlak, N.& Kondo, Andrea& Souza, Polianna Mara Rodrigues de& Pedreira, Wilson Leite…[et al.]. A Child as a Donor for Hematopoietic Stem Cell Transplantation: Bioethical Justification—A Case Study on Sickle Cell Disease. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1146023
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146023
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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