MicroRNA-133b Alleviates Hypoxia Injury by Direct Targeting on NOD-Like Receptor Protein 3 in Rat H9c2 Cardiomyocyte

المؤلفون المشاركون

Zhou, Yongmei
Huang, Hui
Hou, Xiaolin

المصدر

Cardiology Research and Practice

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-11-12

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض

الملخص EN

Objective.

MiR-133b was dysregulated in myocardial infarction.

However, the role and mechanism of miR-133b in myocardial infarction remains unclear.

This study was aimed to explore the role of miR-133b in H9c2 cell injury induced by hypoxia and to investigate the underlying molecular mechanism.

Methods.

Cell injury was assessed by cell viability, migration, invasion, and apoptosis assays.

The expression of miR-133b and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) mRNA was determined by qRT-PCR.

The levels of apoptosis-related proteins and NLRP3 were detected by western blotting.

Results.

Results showed that hypoxia significantly reduced cell viability, migration, and invasion, but increased apoptosis of H9c2 cells.

Downregulation of miR-133b aggravated the cell injury induced by hypoxia.

MiR-133b was directly targeted on NLRP3.

Overexpression of NLRP3 significantly inhibited cell viability, migration, and invasion but induced cell apoptosis in H9c2 treated with hypoxia.

Conclusions.

Thus, miR-133b protects H9c2 against hypoxia injury via downregulation of NLRP3.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhou, Yongmei& Huang, Hui& Hou, Xiaolin. 2019. MicroRNA-133b Alleviates Hypoxia Injury by Direct Targeting on NOD-Like Receptor Protein 3 in Rat H9c2 Cardiomyocyte. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1146075

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhou, Yongmei…[et al.]. MicroRNA-133b Alleviates Hypoxia Injury by Direct Targeting on NOD-Like Receptor Protein 3 in Rat H9c2 Cardiomyocyte. Cardiology Research and Practice No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1146075

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhou, Yongmei& Huang, Hui& Hou, Xiaolin. MicroRNA-133b Alleviates Hypoxia Injury by Direct Targeting on NOD-Like Receptor Protein 3 in Rat H9c2 Cardiomyocyte. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1146075

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1146075