Fibrinogen-to-Albumin Ratio Predicts Contrast-Induced Nephropathy in Patients after Emergency Percutaneous Coronary Intervention

الملخص EN

Background.

The aim of the present study was to investigate the association between fibrinogen-to-albumin ratio (FAR) with contrast-induced nephropathy (CIN) in patients undergoing emergency percutaneous coronary intervention (PCI).

Methods.

565 patients with emergency PCI were consecutively enrolled.

The primary outcome was CIN defined as either a 25% increase in baseline serum creatinine levels or a 0.5 mg/dL (44 μmol/L) increase in absolute serum creatinine levels within 72 h after the contrast medium exposure.

Logistic regression analysis was applied to analyze whether FAR was an independent risk factor for CIN.

Results.

Overall, 29 (5.1%) patients developed CIN.

Compared with the patients without CIN, the patients developing CIN had lower albumin (39.79 ± 3.95 vs.

37.14 ± 5.21, P=0.012) and higher fibrinogen levels (3.51 ± 0.94 vs.

4.14 ± 0.96, P<0.001).

In the multivariate logistic analysis, FAR was an independent predictor of CIN (OR = 3.97; 95% CI, 1.61–9.80; P=0.003) along with perihypotension, age >75 years, and LVEF <45%, and 0.106 was the optimal cutoff value of preprocedural FAR to predict CIN.

Conclusion.

Preprocedural levels of FAR were associated with CIN in patients after emergency PCI.