Association of Autoantibodies against M2-Muscarinic Acetylcholine Receptor with Atrial Fibrosis in Atrial Fibrillation Patients
المؤلفون المشاركون
Liu, Xing-Peng
Ma, Guiling
Wu, Xuejiao
Zeng, Lijun
Jin, Jiawei
Zhang, Jianjun
Zhang, Lin
المصدر
Cardiology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objectives.
To investigate the association of serum autoantibodies against M2-muscarinic acetylcholine receptor (anti-M2-R) with atrial fibrosis in long-standing persistent atrial fibrillation (AF) patients.
Methods.
Twenty-four long-standing persistent AF patients, scheduled to undergo hybrid ablation surgery, were enrolled in the study.
Twenty-six patients with sinus rhythm, scheduled to undergo coronary artery bypass grafting surgery, were enrolled into the non-AF group.
We detected serum anti-M2-R levels.
Left atrial appendages were subjected to histological and molecular biological assays.
Patients in the AF group received follow-up for two years.
Results.
The AF group showed significantly higher serum anti-M2-R levels compared to the non-AF group (496.2 ± 232.5 vs.
86.3 ± 25.7 pmol/L, p<0.001).
The AF group exhibited severe fibrosis in the left atrial appendages, as indicated by increased collagen volume fraction (45.2 ± 4.7% vs.
27.6 ± 8.3%, p<0.001), and higher levels of collagen I (0.52 ± 0.04 vs.
0.24 ± 0.06, p<0.001) and collagen III (0.51 ± 0.07 vs.
0.36 ± 0.09, p<0.001).
TGF-β1 and CTGF were also upregulated in the AF group.
A positive correlation between serum anti-M2-R levels and fibrosis of the left atrial appendage and fibrogenic indexes was observed.
Conclusions.
Serum anti-M2-R levels are higher in AF patients and are associated with the severity of atrial fibrosis.
In addition, serum anti-M2-R levels are positively correlated to TGF-β1 and CTGF expression in the left atrial appendage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Guiling& Wu, Xuejiao& Zeng, Lijun& Jin, Jiawei& Liu, Xing-Peng& Zhang, Jianjun…[et al.]. 2019. Association of Autoantibodies against M2-Muscarinic Acetylcholine Receptor with Atrial Fibrosis in Atrial Fibrillation Patients. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1146081
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Guiling…[et al.]. Association of Autoantibodies against M2-Muscarinic Acetylcholine Receptor with Atrial Fibrosis in Atrial Fibrillation Patients. Cardiology Research and Practice No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1146081
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Guiling& Wu, Xuejiao& Zeng, Lijun& Jin, Jiawei& Liu, Xing-Peng& Zhang, Jianjun…[et al.]. Association of Autoantibodies against M2-Muscarinic Acetylcholine Receptor with Atrial Fibrosis in Atrial Fibrillation Patients. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1146081
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146081
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر