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Critical Care Admission of an HIV Patient with Diabetic Ketoacidosis Secondary to Pembrolizumab
المؤلفون المشاركون
Cuenca, John A.
Laserna, Andres
Reyes, María P.
Nates, Joseph L.
Botz, Gregory H.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-25
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Background.
Pembrolizumab is a checkpoint inhibitor that targets the programmed cell death-1 receptor (PD-1) and has shown to be effective against several malignancies, including lung cancer.
However, life-threatening immune-related adverse events can result from these immunotherapy treatments.
Case presentation.
A 62-year-old man with HIV, metastatic adenocarcinoma of the lung, and no previous history of diabetes presented to the emergency department with new-onset nausea, vomiting, and generalized weakness.
Glucose was 1191 mg/dl, hemoglobin A1c 11%, and potassium 6.9 mEq/L.
He had metabolic acidosis with a lactate of 6.6 mmol/L and anion gap of 38 mEq/L, and ketones were detected on the urinalysis.
Severe diabetic ketoacidosis was diagnosed, and the patient was admitted to the intensive care unit.
Additional investigations showed low C-peptide and negative anti-glutamic acid decarboxylase antibody, anti-insulin antibody, and anti-islet-antigen 2Ab antibody.
After ruling out other possible etiologies, pembrolizumab was considered to be the cause of the diabetes and ketoacidosis.
Conclusions.
Life-threatening adverse drug events associated with checkpoint inhibitors such as pembrolizumab are on the rise.
We recommend to closely follow and monitor patients receiving these immunotherapies.
This strategy could lead to early detection and prevention, as well as reduction of more serious life-threatening complications requiring intensive care.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cuenca, John A.& Laserna, Andres& Reyes, María P.& Nates, Joseph L.& Botz, Gregory H.. 2020. Critical Care Admission of an HIV Patient with Diabetic Ketoacidosis Secondary to Pembrolizumab. Case Reports in Critical Care،Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1146303
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cuenca, John A.…[et al.]. Critical Care Admission of an HIV Patient with Diabetic Ketoacidosis Secondary to Pembrolizumab. Case Reports in Critical Care No. 2020 (2020), pp.1-3.
https://search.emarefa.net/detail/BIM-1146303
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cuenca, John A.& Laserna, Andres& Reyes, María P.& Nates, Joseph L.& Botz, Gregory H.. Critical Care Admission of an HIV Patient with Diabetic Ketoacidosis Secondary to Pembrolizumab. Case Reports in Critical Care. 2020. Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1146303
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146303
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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