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Nonsmall Cell Lung Carcinoma with Giant Cell Features Expressing Programmed Death-Ligand 1: A Report of a Patient Successfully Treated with Pembrolizumab
المؤلفون المشاركون
Nakayama, Shingo
Minematsu, Naoto
Sasaki, Mamoru
Morinaga, Shojiroh
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-15
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Giant cell carcinoma, a rare variant of nonsmall cell lung carcinoma (NSCLC), is characterized by aggressive progression and poor response to conventional chemotherapy.
This report is the first to describe a patient with NSCLC and giant cell features who was successfully treated with pembrolizumab, an antibody targeting programmed death-1 (PD-1).
A 69-year-old woman was diagnosed with NSCLC with multiple brain metastases.
Histological evaluation of lung biopsy specimens revealed proliferation of pleomorphic giant tumor cells with poor cohesiveness, findings consistent with giant cell carcinoma.
Immunostaining showed that a high proportion of the tumor cells were positive for expression of programmed death-ligand 1 (PD-L1).
The patient received stereotactic radiotherapy for the brain metastases, followed by administration of pembrolizumab.
Treatment with pembrolizumab resulted in the rapid regression of the primary lung nodule, with the progression-free period maintained for at least four treatment cycles.
Immunotherapy targeting PD-1/PD-L1 may be an option for patients with PD-L1-positive NSCLC with giant cell features.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nakayama, Shingo& Sasaki, Mamoru& Morinaga, Shojiroh& Minematsu, Naoto. 2018. Nonsmall Cell Lung Carcinoma with Giant Cell Features Expressing Programmed Death-Ligand 1: A Report of a Patient Successfully Treated with Pembrolizumab. Case Reports in Oncological Medicine،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1146493
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nakayama, Shingo…[et al.]. Nonsmall Cell Lung Carcinoma with Giant Cell Features Expressing Programmed Death-Ligand 1: A Report of a Patient Successfully Treated with Pembrolizumab. Case Reports in Oncological Medicine No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1146493
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nakayama, Shingo& Sasaki, Mamoru& Morinaga, Shojiroh& Minematsu, Naoto. Nonsmall Cell Lung Carcinoma with Giant Cell Features Expressing Programmed Death-Ligand 1: A Report of a Patient Successfully Treated with Pembrolizumab. Case Reports in Oncological Medicine. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1146493
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146493
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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