Ligneous Periodontitis in a Patient with Type 1 Plasminogen Deficiency: A Case Report and Review of the Literature
المؤلفون المشاركون
Sadasivan, Arun
Ramesh, Roshni
Mathew, Deepu George
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Ligneous periodontitis or destructive membranous periodontal disease is a rare condition involving gingival tissues, which is due to plasminogen deficiency and fibrin deposition.
Plasminogen deficiency is an ultrarare autosomal recessive disease.
The disease is characterized by gingival enlargement and periodontal tissue destruction that leads to rapid tooth loss despite treatment attempts.
A defect in fibrinolysis and abnormal wound healing are the main pathogenesis of this condition.
It is caused by mutations in PLG, the gene coding for plasminogen, which results in decreased levels and functional activity.
Case Presentation.
In this case report, clinical and histopathological findings of a 26-year-old male patient who presented with generalized membranous gingival enlargement are presented.
He was the third child of consanguineous parents and had multicystic congenital hydrocephalus at birth.
Besides the gingival enlargement, he also presented ligneous conjunctivitis since childhood.
The intraoral examination revealed generalized periodontal breakdown.
Radiographs showed alveolar bone loss present in every quadrant.
All blood investigations were normal except for plasminogen deficiency.
A biopsy sample was excised from affected gingiva and a series of histopathological evaluation was performed.
Based on clinical and histopathological evidence, a diagnosis of destructive membranous periodontal disease or ligneous periodontitis was made.
A clinical exome assay for the PLG gene was also done.
It was confirmed as Type 1 plasminogen deficiency.
Conclusion.
Ligneous periodontitis has been rarely reported in India.
The reasons could be because of the rarity of the disease or missed diagnosis.
The need to take a proper history and perform a proper clinical examination and histopathologic evaluation has to be stressed when diagnosing and treating gingival enlargements.
If a genetic condition is suspected, genetic screening is also needed.
All these will help the clinician in correctly diagnosing the disease and formulating a proper treatment plan for managing the condition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sadasivan, Arun& Ramesh, Roshni& Mathew, Deepu George. 2020. Ligneous Periodontitis in a Patient with Type 1 Plasminogen Deficiency: A Case Report and Review of the Literature. Case Reports in Dentistry،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1146514
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sadasivan, Arun…[et al.]. Ligneous Periodontitis in a Patient with Type 1 Plasminogen Deficiency: A Case Report and Review of the Literature. Case Reports in Dentistry No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1146514
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sadasivan, Arun& Ramesh, Roshni& Mathew, Deepu George. Ligneous Periodontitis in a Patient with Type 1 Plasminogen Deficiency: A Case Report and Review of the Literature. Case Reports in Dentistry. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1146514
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146514
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر