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Antiphospholipid Syndrome: Multiple Manifestations in a Single Patient—A High Suspicion Is Still Needed
المؤلفون المشاركون
Garcia, Gwenalyn
Ibrahim, Uroosa
Kedia, Shiksha
Atallah, Jean Paul
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-23
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Antiphospholipid Syndrome (APS) is an autoimmune disorder with clinical and laboratory features of vascular thrombosis, pregnancy loss, and persistent antiphospholipid antibodies (aPLs).
The pathophysiology is thought to involve the activation of endothelial cells, monocytes, platelets, and complement by aPLs.
Disease can range from asymptomatic to rapidly fatal catastrophic APS.
We present a case of a 34-year-old male referred for pancytopenia and splenomegaly.
On examination, he had decreased sensation and 4/5 power in the left upper extremity.
A lacy, purplish rash was noted on the trunk and upper extremity.
MRI of brain showed acute/subacute lacunar infarctions.
Laboratory studies revealed an elevated lactate dehydrogenase level, bilirubin and ferritin, decreased haptoglobin, and positive Coombs test.
Antinuclear antibody test was negative and antiphospholipid antibody panel revealed positivity for anti-cardiolipin IgG and IgM, antiphosphatidylserine IgG, and anti-β2-glycoprotein IgG.
The patient was diagnosed with primary APS.
Pancytopenia is relatively rare in primary APS and is more often seen in secondary APS.
Our patient demonstrated involvement of multiple organ systems as well as livedo reticularis and autoimmune-related findings such as Raynaud phenomenon and Coombs positive hemolytic anemia.
We discuss the various clinical and laboratory findings in patients with APS that aid in diagnosis, as well as important management considerations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ibrahim, Uroosa& Kedia, Shiksha& Garcia, Gwenalyn& Atallah, Jean Paul. 2017. Antiphospholipid Syndrome: Multiple Manifestations in a Single Patient—A High Suspicion Is Still Needed. Case Reports in Medicine،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146798
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ibrahim, Uroosa…[et al.]. Antiphospholipid Syndrome: Multiple Manifestations in a Single Patient—A High Suspicion Is Still Needed. Case Reports in Medicine No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1146798
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ibrahim, Uroosa& Kedia, Shiksha& Garcia, Gwenalyn& Atallah, Jean Paul. Antiphospholipid Syndrome: Multiple Manifestations in a Single Patient—A High Suspicion Is Still Needed. Case Reports in Medicine. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1146798
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146798
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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