ABCB1 Polymorphisms and Drug-Resistant Epilepsy in a Tunisian Population
المؤلفون المشاركون
Klaa, Hedia
Ben Youssef Turki, Ilhem
Chouchi, Malek
Hila, Lamia
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-02
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Background.
Epilepsy is one of the most common neurological disorders with about 30% treatment failure rate.
An interindividual variations in efficacy of antiepileptic drugs (AEDs) make the treatment of epilepsy challenging, which can be attributed to genetic factors such as ATP-Binding Cassette sub-family B, member1 (ABCB1) gene polymorphisms.
Objective.
The main objective of the present study is to evaluate the association of ABCB1 C1236T, G2677T, and C3435T polymorphisms with treatment response among Tunisian epileptic patients.
Materials and Methods.
One hundred epileptic patients, originated from north of Tunisia, were recruited and categorized into 50 drug-resistant and 50 drug-responsive patients treated with antiepileptic drugs (AEDs) as per the International League Against Epilepsy.
DNA of patients was extracted and ABCB1 gene polymorphisms studied using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
Results.
The C1236T, G2677T, and C3435T polymorphisms were involved into AED resistance.
Significant genotypic (C1236T TT (p≤0.001); G2677T TT (p=0.001); C3435T TT (p≤0.001)) and allelic associations (C1236T T (3.650, p≤0.001); G2677TT (1.801, p=0.044); C3435T T (4.730, p≤0.001)) with drug resistance epilepsy (DRE) were observed.
A significant level of linkage disequilibrium (LD) was also noted between ABCB1 polymorphisms.
Patients with the haplotypes CT and TT (C1236T-G2677T); GT, TC, and TT (G2677T-C3435T); CT and TT (C1236T-C3435T); CTT, TTC, TGT, and TTT (C1236T-G2677T-C3435T) were also significantly associated to AED resistance.
Conclusions.
The response to antiepileptics seems to be modulated by TT genotypes, T alleles, and the predicted haplotypes for the tested SNPs in our population.
Genetic analysis is a valuable tool for predicting treatment response and thus will contribute to personalized medicine for Tunisian epileptic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chouchi, Malek& Klaa, Hedia& Ben Youssef Turki, Ilhem& Hila, Lamia. 2019. ABCB1 Polymorphisms and Drug-Resistant Epilepsy in a Tunisian Population. Disease Markers،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1146864
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chouchi, Malek…[et al.]. ABCB1 Polymorphisms and Drug-Resistant Epilepsy in a Tunisian Population. Disease Markers No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1146864
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chouchi, Malek& Klaa, Hedia& Ben Youssef Turki, Ilhem& Hila, Lamia. ABCB1 Polymorphisms and Drug-Resistant Epilepsy in a Tunisian Population. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1146864
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146864
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر