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Effect of N(Epsilon)-(carboxymethyl)lysine on Laboratory Parameters and Its Association with βS Haplotype in Children with Sickle Cell Anemia
المؤلفون المشاركون
Goncalves, Marilda Souza
Ndidi, Uche Samuel
Adanho, Corynne Stephanie Ahouefa
Santiago, Rayra Pereira
Yahouédéhou, Sètondji Cocou Modeste Alexandre
Santana, Sânzio Silva
Mafili, Vitor Valério
Pitanga, Thassila Nogueira
Fonseca, Cleverson Alves
Ferreira, Junia Raquel Dutra
Adorno, Elisângela Vitoria
Lyra, Isa Menezes
Adekile, Adekunle D.
Barbosa, Cynara Gomes
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The present study aimed to investigate the association of Nε-carboxymethyllysine (CML) with laboratory parameters and βS haplotypes in pediatric sickle cell anemia (SCA) patients with or without hydroxyurea (HU) therapy.
We included 55 children with SCA (SCAtotal), where 27 were on HU treatment (SCA-HU+) and 28 without HU treatment (SCA-HU-).
Laboratory characteristics were determined using electronic methods while CML was measured using competitive ELISA.
βS haplotypes were determined by RFLP-PCR.
Significant increases in MCV and MCH and significant decreases in leukocytes, eosinophils, basophils, atypical lymphocytes, lymphocytes, and monocytes were found in SCA-HU+ compared to SCA-HU-.
SCA-HU+ presented significant reduction in aspartate transaminase and lactate dehydrogenase and increase in creatinine levels compared to SCA-HU-.
CML levels were significantly higher in both SCA-HU+ and SCA-HU- compared to the healthy control.
In addition, a negative correlation was found between CML and alanine transaminase in SCA-HU+ and SCAtotal (p<0.01).
A significant association was found between CML levels and βS haplotypes.
The results suggest that CML has a role to play in SCA complications, independent of HU therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ndidi, Uche Samuel& Adanho, Corynne Stephanie Ahouefa& Santiago, Rayra Pereira& Yahouédéhou, Sètondji Cocou Modeste Alexandre& Santana, Sânzio Silva& Mafili, Vitor Valério…[et al.]. 2019. Effect of N(Epsilon)-(carboxymethyl)lysine on Laboratory Parameters and Its Association with βS Haplotype in Children with Sickle Cell Anemia. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1146884
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ndidi, Uche Samuel…[et al.]. Effect of N(Epsilon)-(carboxymethyl)lysine on Laboratory Parameters and Its Association with βS Haplotype in Children with Sickle Cell Anemia. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1146884
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ndidi, Uche Samuel& Adanho, Corynne Stephanie Ahouefa& Santiago, Rayra Pereira& Yahouédéhou, Sètondji Cocou Modeste Alexandre& Santana, Sânzio Silva& Mafili, Vitor Valério…[et al.]. Effect of N(Epsilon)-(carboxymethyl)lysine on Laboratory Parameters and Its Association with βS Haplotype in Children with Sickle Cell Anemia. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1146884
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146884
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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