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Pernicious Anemia Associated Cobalamin Deficiency and Thrombotic Microangiopathy: Case Report and Review of the Literature
المؤلفون المشاركون
Yousaf, Farhanah
Spinowitz, Bruce
Charytan, Chaim
Galler, Marilyn
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
A 43-year-old Hispanic male without significant previous medical history was brought to emergency department for syncope following a blood draw to investigate a 40 lbs weight loss during the past 6 months associated with decreased appetite and progressive fatigue.
The patient also reported a 1-month history of jaundice.
On examination, he was hemodynamically stable and afebrile with pallor and diffuse jaundice but without skin rash or palpable purpura.
Normal sensations and power in all extremities were evident on neurological exam.
Presence of hemolytic anemia, schistocytosis, thrombocytopenia, and elevated lactate dehydrogenase (LDH) was suggestive of thrombotic thrombocytopenic purpura (TTP).
However, presence of leukopenia, macrocytes, and an inadequate reticulocyte response to the degree of anemia served as initial clues to an alternative diagnosis.
Two and one units of packed red blood cells were transfused on day 1 and day 3, respectively.
In addition, one unit of platelets was transfused on day 2.
Daily therapeutic plasma exchange (TPE) was initiated and continued until ADAMTS-13 result ruled out TTP.
A low cobalamin (vitamin B12) level was evident at initial laboratory work-up and subsequent testing revealed positive intrinsic factor-blocking antibodies supporting a diagnosis of pernicious anemia with severe cobalamin deficiency.
Hematological improvement was observed following vitamin B12 supplementation.
The patient was discharged and markedly improved on day 9 with outpatient follow-up for cobalamin supplementation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yousaf, Farhanah& Spinowitz, Bruce& Charytan, Chaim& Galler, Marilyn. 2017. Pernicious Anemia Associated Cobalamin Deficiency and Thrombotic Microangiopathy: Case Report and Review of the Literature. Case Reports in Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1146919
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yousaf, Farhanah…[et al.]. Pernicious Anemia Associated Cobalamin Deficiency and Thrombotic Microangiopathy: Case Report and Review of the Literature. Case Reports in Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1146919
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yousaf, Farhanah& Spinowitz, Bruce& Charytan, Chaim& Galler, Marilyn. Pernicious Anemia Associated Cobalamin Deficiency and Thrombotic Microangiopathy: Case Report and Review of the Literature. Case Reports in Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1146919
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146919
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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