Prognostic Significance of CIP2A in Esophagogastric Junction Adenocarcinoma: A Study of 65 Patients and a Meta-Analysis
المؤلفون المشاركون
Zhu, Xueping
Li, Yanhong
Wang, Mei
Cao, Xu
Wu, Yi
Fang, Fang
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
The expression of the cancerous inhibitor protein phosphatase 2A (CIP2A) appears to be predictive of the prognosis of various solid tumors.
However, the association between this protein and the risk of esophagogastric junction adenocarcinoma (EGJA) remains unclear.
We investigated CIP2A expression and its clinical significance in EGJA and conducted a meta-analysis to explore the relationship between CIP2A and the prognosis of patients with solid tumors.
Methods.
Immunohistochemistry (IHC) was performed to detect the expression of CIP2A in EGJA.
Kaplan-Meier estimation, Cox analysis, and ROC curves were performed to analyze the survival of patients and the prognostic factors.
In the meta-analysis, we searched relevant publications in several widely used databases and used 15 studies (2348 patients).
Results.
IHC demonstrated that CIP2A was elevated in EGJA and correlated with poor survival as an independent indicator.
It could forecast the survival more precisely when combined with the grade, which is another independent prognosis marker of EGJA.
Meta-analysis demonstrated that the associations between the expression of CIP2A and the prognosis were detected for overall survival (HR=1.98, 95%CI=1.69‐2.32), disease-specific survival (HR=1.72, 95%CI=1.50‐1.97), and time to tumor progression (pooled HR=1.95, 95%CI=1.56‐2.43).
Conclusion.
High expression of CIP2A was a poor indicator of the prognosis of EGJA, and CIP2A may be a new biomarker for the diagnosis and treatment of EGJA.
The meta-analysis suggested that CIP2A expression can be a predictive marker of overall survival, disease-specific survival, and time to tumor progression in patients with solid tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yanhong& Wang, Mei& Zhu, Xueping& Cao, Xu& Wu, Yi& Fang, Fang. 2019. Prognostic Significance of CIP2A in Esophagogastric Junction Adenocarcinoma: A Study of 65 Patients and a Meta-Analysis. Disease Markers،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1146942
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yanhong…[et al.]. Prognostic Significance of CIP2A in Esophagogastric Junction Adenocarcinoma: A Study of 65 Patients and a Meta-Analysis. Disease Markers No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1146942
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yanhong& Wang, Mei& Zhu, Xueping& Cao, Xu& Wu, Yi& Fang, Fang. Prognostic Significance of CIP2A in Esophagogastric Junction Adenocarcinoma: A Study of 65 Patients and a Meta-Analysis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1146942
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146942
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر