Optimizing the Use of the Gamma-Glutamyl Transpeptidase-to-Platelet Ratio and Transient Elastography to Identify Liver Cirrhosis in Patients with Chronic Hepatitis B Concurrent with Nonalcoholic Fatty Liver Disease
المؤلفون المشاركون
Gao, Zhiliang
Zhang, Geng-lin
Zhang, Ting
Chen, Zheng
Xu, Shi-cheng
Zeng, Jie
Li, Yi-Ping
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background and Aim.
Little information is available about the assessment and optimal use of the gamma-glutamyl transpeptidase-to-platelet ratio (GPR) and transient elastography (TE) in predicting liver cirrhosis in patients with chronic hepatitis B (CHB) and concurrent nonalcoholic fatty liver disease (NAFLD).
This study is aimed at comparing their diagnostic performances and developing an optimal approach for predicting liver cirrhosis in CHB patients with NAFLD.
Methods.
Consecutive CHB patients with NAFLD were enrolled.
The GPR was calculated, and TE was performed using liver biopsy as a reference standard.
The accuracy of predicting liver cirrhosis using GPR and TE was assessed and compared, and an optimal approach was developed.
Results.
Both TE and GPR correlated significantly with the histological fibrosis stage.
TE and GPR had excellent performance in predicting liver cirrhosis, and the comparison of areas under the receiver operating characteristic curves revealed that TE was superior to GPR (0.95 vs.
0.85, P=0.039).
Moreover, the dual cutoffs established by the likelihood ratio showed that GPR had a similar misclassification but higher indeterminate rate than TE (54.5% vs.
11.7%, P<0.001).
Additionally, a 2-step approach using GPR followed by TE had comparable performance to that of both GPR and TE tests for all patients (misclassification: 8.9% vs.
8.3%, P=0.866; indeterminate rate: 15.2% vs.
17.2%, P=0.750) but could reduce TE scans by approximately one-third.
Conclusions.
Both TE and GPR show excellent performance in predicting liver cirrhosis in CHB patients with NAFLD.
The 2-step approach using GPR followed by TE may be optimal for the assessment of cirrhosis in CHB patients with NAFLD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Geng-lin& Xu, Shi-cheng& Zeng, Jie& Chen, Zheng& Li, Yi-Ping& Zhang, Ting…[et al.]. 2019. Optimizing the Use of the Gamma-Glutamyl Transpeptidase-to-Platelet Ratio and Transient Elastography to Identify Liver Cirrhosis in Patients with Chronic Hepatitis B Concurrent with Nonalcoholic Fatty Liver Disease. Disease Markers،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1146987
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Geng-lin…[et al.]. Optimizing the Use of the Gamma-Glutamyl Transpeptidase-to-Platelet Ratio and Transient Elastography to Identify Liver Cirrhosis in Patients with Chronic Hepatitis B Concurrent with Nonalcoholic Fatty Liver Disease. Disease Markers No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1146987
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Geng-lin& Xu, Shi-cheng& Zeng, Jie& Chen, Zheng& Li, Yi-Ping& Zhang, Ting…[et al.]. Optimizing the Use of the Gamma-Glutamyl Transpeptidase-to-Platelet Ratio and Transient Elastography to Identify Liver Cirrhosis in Patients with Chronic Hepatitis B Concurrent with Nonalcoholic Fatty Liver Disease. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1146987
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146987
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر