The Elevated Serum Level of IFN-γ in Patients with Failed Back Surgery Syndrome Remains Unchanged after Spinal Cord Stimulation
المؤلفون المشاركون
Bojarska-Junak, Agnieszka
Kamieniak, Piotr
Bielewicz, Joanna
Grochowski, Cezary
Litak, Jakub
Daniluk, Beata
Trojanowski, Tomasz
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objectives.
We investigated the influence of spinal cord stimulation (SCS) on IFN-γ, IL-1β, IL-6, TNF-α, IL-10, and TGF-β serum levels in failed back surgery syndrome (FBSS) patients.
The study will try to give new insights into the mechanism of SCS action and the role of IFN-γ and other cytokines in neuropathic pain (NP) development.
Materials and Methods.
Clinical and biochemical assessment was conducted in four groups of patients: group 0 consisted of 24 FBSS patients qualified to SCS therapy, group 1 included 17 patients who were one month after implantation, group 2 featured 12 patients who were 3 months after the implantation, and group C (the control group) with no NP.
Clinical status was assessed with the use of Numeric Rating Scale (NRS), the Pain Rating Index of McGill Pain Questionnaire (SF-MPQ), the Oswestry Disability Index (ODI), and Beck Depression Inventory (BDI).
The plasma concentrations of IFN-γ were ascertained by an immunoenzymatic method.
Results.
We found a significant difference between the patients before SCS and controls’ serum level of IFN-γ.
Similarly, a significantly higher level of TNF-α and significantly lower level of IL-10 in FBSS patients than controls were observed.
The significant differences were not observed between SCS patients 3 months after the procedure and controls’ serum level of IFN-γ and other cytokines.
We noticed a positive correlation between IFN-γ concentration with NRS back value before SCS and positive correlation between IFN-γ concentration after SCS with NRS leg value before SCS.
Higher IFN-γ concentrations accompanied higher NRS values.
Levels of TGF-β and IL-10 may correlate with physical ability and depressive behavior.
Conclusions.
SCS did not influence serum cytokine levels significantly.
Serum concentration of IFN-γ may be recognized as an occasional pain factor because of its significantly higher level in FBSS patients versus controls and higher IFN-γ value accompanying higher pain intensity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kamieniak, Piotr& Bielewicz, Joanna& Grochowski, Cezary& Litak, Jakub& Bojarska-Junak, Agnieszka& Daniluk, Beata…[et al.]. 2019. The Elevated Serum Level of IFN-γ in Patients with Failed Back Surgery Syndrome Remains Unchanged after Spinal Cord Stimulation. Disease Markers،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1146992
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kamieniak, Piotr…[et al.]. The Elevated Serum Level of IFN-γ in Patients with Failed Back Surgery Syndrome Remains Unchanged after Spinal Cord Stimulation. Disease Markers No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1146992
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kamieniak, Piotr& Bielewicz, Joanna& Grochowski, Cezary& Litak, Jakub& Bojarska-Junak, Agnieszka& Daniluk, Beata…[et al.]. The Elevated Serum Level of IFN-γ in Patients with Failed Back Surgery Syndrome Remains Unchanged after Spinal Cord Stimulation. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1146992
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146992
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر