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The Elevated Serum Level of IFN-γ in Patients with Failed Back Surgery Syndrome Remains Unchanged after Spinal Cord Stimulation
المؤلفون المشاركون
Bojarska-Junak, Agnieszka
Kamieniak, Piotr
Bielewicz, Joanna
Grochowski, Cezary
Litak, Jakub
Daniluk, Beata
Trojanowski, Tomasz
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objectives.
We investigated the influence of spinal cord stimulation (SCS) on IFN-γ, IL-1β, IL-6, TNF-α, IL-10, and TGF-β serum levels in failed back surgery syndrome (FBSS) patients.
The study will try to give new insights into the mechanism of SCS action and the role of IFN-γ and other cytokines in neuropathic pain (NP) development.
Materials and Methods.
Clinical and biochemical assessment was conducted in four groups of patients: group 0 consisted of 24 FBSS patients qualified to SCS therapy, group 1 included 17 patients who were one month after implantation, group 2 featured 12 patients who were 3 months after the implantation, and group C (the control group) with no NP.
Clinical status was assessed with the use of Numeric Rating Scale (NRS), the Pain Rating Index of McGill Pain Questionnaire (SF-MPQ), the Oswestry Disability Index (ODI), and Beck Depression Inventory (BDI).
The plasma concentrations of IFN-γ were ascertained by an immunoenzymatic method.
Results.
We found a significant difference between the patients before SCS and controls’ serum level of IFN-γ.
Similarly, a significantly higher level of TNF-α and significantly lower level of IL-10 in FBSS patients than controls were observed.
The significant differences were not observed between SCS patients 3 months after the procedure and controls’ serum level of IFN-γ and other cytokines.
We noticed a positive correlation between IFN-γ concentration with NRS back value before SCS and positive correlation between IFN-γ concentration after SCS with NRS leg value before SCS.
Higher IFN-γ concentrations accompanied higher NRS values.
Levels of TGF-β and IL-10 may correlate with physical ability and depressive behavior.
Conclusions.
SCS did not influence serum cytokine levels significantly.
Serum concentration of IFN-γ may be recognized as an occasional pain factor because of its significantly higher level in FBSS patients versus controls and higher IFN-γ value accompanying higher pain intensity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kamieniak, Piotr& Bielewicz, Joanna& Grochowski, Cezary& Litak, Jakub& Bojarska-Junak, Agnieszka& Daniluk, Beata…[et al.]. 2019. The Elevated Serum Level of IFN-γ in Patients with Failed Back Surgery Syndrome Remains Unchanged after Spinal Cord Stimulation. Disease Markers،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1146992
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kamieniak, Piotr…[et al.]. The Elevated Serum Level of IFN-γ in Patients with Failed Back Surgery Syndrome Remains Unchanged after Spinal Cord Stimulation. Disease Markers No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1146992
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kamieniak, Piotr& Bielewicz, Joanna& Grochowski, Cezary& Litak, Jakub& Bojarska-Junak, Agnieszka& Daniluk, Beata…[et al.]. The Elevated Serum Level of IFN-γ in Patients with Failed Back Surgery Syndrome Remains Unchanged after Spinal Cord Stimulation. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1146992
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146992
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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