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CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas
المؤلفون المشاركون
Chang, Lin-Li
Lee, Yi-Chen
Hsu, Wei-Chi
Liang, Peir-In
Huang, A-Mei
Lin, Hui-Hui
Wu, Wen-Jeng
Li, Ching-Chia
Li, Wei-Ming
Jhan, Jhen-Hao
Ke, Hung-Lung
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Colony-stimulating factor-1 (CSF-1) is a homodimeric glycoprotein.
The main role of CSF-1 is as a hematopoietic growth factor that modulates proliferation, differentiation, and survival of macrophages.
Moreover, CSF-1 has also been reported to be aberrantly expressed in several human cancers.
However, the precise role of CSF-1 in upper tract urothelial carcinomas (UTUC) has not been studied.
In this research, we examined the clinical significance of CSF-1 expression in UTUC.
Materials and Methods.
One hundred twelve cancer tissue samples of UTUC from patients were included in this study, and the other cohort of 35 UTUC were paired cancer-adjacent normal samples.
CSF-1 expression was evaluated by immunohistochemistry, and the association of CSF-1 expression with different clinicopathological variables was analyzed.
Results.
CSF-1 expression was higher in UTUC than in the normal urothelium (P=0.005).
The CSF-1 expression was primarily localized in the nucleus and was significantly correlated with tumor size (P=0.04) and patients who had a high stage (P<0.001), distant metastasis (P=0.006), recurrence (P=0.003), and cancer death (P=0.005).
High CSF-1 expression was correlated with poor disease-free survival (P=0.008) and cancer-specific survival (P=0.001).
Our results also used univariate and multivariable analyses, which found that high CSF-1 expression was an independent predictor of poor disease-free survival (hazard ratio=2.56; P=0.007) and cancer-specific survival (hazard ratio=5.14; P=0.022).
Conclusions.
Our findings indicate that the expression of CSF-1 is a potential prognostic marker for predicting patient survival and recurrence in UTUC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hsu, Wei-Chi& Lee, Yi-Chen& Liang, Peir-In& Chang, Lin-Li& Huang, A-Mei& Lin, Hui-Hui…[et al.]. 2019. CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas. Disease Markers،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147004
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hsu, Wei-Chi…[et al.]. CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas. Disease Markers No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1147004
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hsu, Wei-Chi& Lee, Yi-Chen& Liang, Peir-In& Chang, Lin-Li& Huang, A-Mei& Lin, Hui-Hui…[et al.]. CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147004
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147004
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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