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NFE2L3 Inhibition Induces Cell Cycle Arrest at the G0G1 Phase in Colorectal Cancer Cells through Downregulating CCND1 and pRb1-ser807811
المؤلفون المشاركون
Tan, Zhi-Rong
Zhou, Hong-Hao
Zhang, Lihua
Tang, Baiyou
Cheng, Yu
Jiao, Chuan
Hu, Dong-Li
Cheng, Lin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The molecular mechanism for colorectal cancer to develop remains unelucidated.
To find biomarkers related to colorectal cancer development, we analyzed the gene expression profile of 380 colorectal cancer patients and 51 healthy controls by R software.
Finally, 1579 upregulated differential expression genes (DEGs) and 3218 downregulated DEGs were identified.
Then, the top 20 upregulated DEGs were compared with 181 upregulated DEGs that we reported previously, and 11 overlapped DEGs were found.
NFE2L3 (nuclear factor, erythroid 2-like 3) was among those overlapped DEGs and was rarely reported in colorectal cancer.
Real-time polymerase chain reaction (PCR) results showed that higher NFE2L3 expression levels were identified in paired tumor samples than in paratumor samples (48 paired samples).
Flow cytometry analysis revealed that the cell cycle was arrested at the G0/G1 phase after inhibition of NFE2L3 in both HCT116 and SW480 cell lines.
Western blot detection showed that CCND1 and phosphorylated Rb transcriptional corepressor 1 at ser-807/811 (pRb1-ser807/811) expression levels were downregulated when NFE2L3 was inhibited in those two cell lines.
A significant positive correlation was observed between NFE2L3 and CCND1 expression levels in colorectal tissue samples.
These evidences indicate that downregulation of NFE2L3 induces cell cycle arrest at the G0/G1 phase through downregulation of CCND1 and pRb1-ser807/811.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Lihua& Hu, Dong-Li& Tang, Baiyou& Cheng, Yu& Jiao, Chuan& Cheng, Lin…[et al.]. 2019. NFE2L3 Inhibition Induces Cell Cycle Arrest at the G0G1 Phase in Colorectal Cancer Cells through Downregulating CCND1 and pRb1-ser807811. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147021
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Lihua…[et al.]. NFE2L3 Inhibition Induces Cell Cycle Arrest at the G0G1 Phase in Colorectal Cancer Cells through Downregulating CCND1 and pRb1-ser807811. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1147021
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Lihua& Hu, Dong-Li& Tang, Baiyou& Cheng, Yu& Jiao, Chuan& Cheng, Lin…[et al.]. NFE2L3 Inhibition Induces Cell Cycle Arrest at the G0G1 Phase in Colorectal Cancer Cells through Downregulating CCND1 and pRb1-ser807811. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147021
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147021
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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