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Plasma Osteoprotegerin Correlates with Stroke Severity and the Occurrence of Microembolic Signals in Patients with Acute Ischemic Stroke
المؤلفون المشاركون
Pan, Xudong
Cao, Yanyan
Cui, Congxian
Zhao, Hongqin
Li, Wenjian
Wang, Kun
Ma, Aijun
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Instability of atherosclerotic plaques is associated with the occurrence of stroke.
Microembolic signals (MESs) are an indicator of unstable plaque.
A relationship between plasma osteoprotegerin (OPG) and ischemic stroke has already been identified.
The aim of this study was to investigate whether plasma OPG levels have a relationship with MESs and to evaluate the feasibility of OPG as a biomarker of stroke severity and occurrence of MESs.
Methods.
Our study consisted of 127 patients with large artery atherosclerosis stroke and 56 controls.
Patients were classified into subgroups based on stroke severity and the occurrence of MESs.
MES-monitoring was performed for 60 min using transcranial Doppler within 72 h of stroke onset.
Stroke severity at admission was assessed by the National Institutes of Health Stroke Scale.
Results.
Plasma OPG levels were significantly associated with stroke, MESs, and stroke severity at admission (adjusted OR [95% CI]: 1.002 [1.001–1.003] p<0.001; 1.002 [1.001–1.003] p=0.001; 1.001 [1.000–1.002] p=0.028).
When plasma OPG levels were used to determine the stroke severity, the area under the receiver-operating characteristic curve (AUC) was 0.734 (95% CI: 0.625-0.843) based on a cutoff value of 1998.44 pg/ml; the sensitivity and specificity of this test were 80.6% and 65.6%, respectively.
Furthermore, when the levels of OPG were used to distinguish the presence of MESs, the AUC was 0.766 (95% CI: 0.672-0.860); the cutoff value was 2107.91 pg/ml.
The sensitivity of this cutoff value was 68.8% and the specificity was 73.7%.
Conclusions.
Plasma OPG levels correlate with stroke severity and the occurrence of MESs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Yanyan& Cui, Congxian& Zhao, Hongqin& Pan, Xudong& Li, Wenjian& Wang, Kun…[et al.]. 2019. Plasma Osteoprotegerin Correlates with Stroke Severity and the Occurrence of Microembolic Signals in Patients with Acute Ischemic Stroke. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147040
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Yanyan…[et al.]. Plasma Osteoprotegerin Correlates with Stroke Severity and the Occurrence of Microembolic Signals in Patients with Acute Ischemic Stroke. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1147040
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Yanyan& Cui, Congxian& Zhao, Hongqin& Pan, Xudong& Li, Wenjian& Wang, Kun…[et al.]. Plasma Osteoprotegerin Correlates with Stroke Severity and the Occurrence of Microembolic Signals in Patients with Acute Ischemic Stroke. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147040
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147040
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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