Dapagliflozin-Induced Acute Pancreatitis: A Case Report and Review of Literature
المؤلفون المشاركون
Sujanani, Sunam M.
Elfishawi, Mohanad M.
Zarghamravanbaksh, Paria
Castillo, Francisco J. Cuevas
Reich, David M.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-15
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are increasingly used as add-on therapy in patients with poorly controlled type 2 diabetes mellitus (T2DM).
Although pancreatitis is not a known side effect of SGLT-2 inhibitors, there have been case reports of SGLT-2 inhibitor use being associated with pancreatitis.
Case Presentation.
A 51-year-old male with a history of type 2 diabetes, dyslipidemia, and status-post cholecystectomy presented to the emergency room with a four-day history of periumbilical pain radiating to the back.
He denied any history of recent alcohol intake or prior episodes of pancreatitis.
On physical examination, his abdomen was diffusely tender to palpation without guarding or rebound.
Initial labs were notable for a leukocyte count of 9.3 × 109/L, creatinine level of 0.72 mg/dL, calcium level of 9.5 mg/dL, lipase level of 262 U/L, and triglyceride level of 203 mg/dL.
His last HbA1c was 8.5%.
CT scan of his abdomen and pelvis showed findings consistent with acute pancreatitis with no biliary ductal dilatation.
Careful review of his medications revealed the patient was recently started on dapagliflozin five days prior to admission in addition to his longstanding regimen of insulin detemir, sitagliptin, metformin, and rosuvastatin.
His symptoms resolved after discontinuation of sitagliptin and dapagliflozin.
A year later, due to increasing HbA1c levels, a decision was made to rechallenge the patient with dapagliflozin, after which he developed another episode of acute pancreatitis.
His symptoms resolved upon cessation of dapagliflozin.
Conclusion.
This case highlights the possible association of SGLT-2 inhibitors and pancreatitis.
Patients should be informed about the symptoms of acute pancreatitis and advised to discontinue SGLT-2 inhibitors in case such symptoms occur.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sujanani, Sunam M.& Elfishawi, Mohanad M.& Zarghamravanbaksh, Paria& Castillo, Francisco J. Cuevas& Reich, David M.. 2020. Dapagliflozin-Induced Acute Pancreatitis: A Case Report and Review of Literature. Case Reports in Endocrinology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147058
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sujanani, Sunam M.…[et al.]. Dapagliflozin-Induced Acute Pancreatitis: A Case Report and Review of Literature. Case Reports in Endocrinology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1147058
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sujanani, Sunam M.& Elfishawi, Mohanad M.& Zarghamravanbaksh, Paria& Castillo, Francisco J. Cuevas& Reich, David M.. Dapagliflozin-Induced Acute Pancreatitis: A Case Report and Review of Literature. Case Reports in Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147058
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147058
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر