Current Approach of Functioning Head and Neck Paragangliomas: Case Report of a Young Patient with Multiple Asynchronous Tumors
المؤلفون المشاركون
Ramírez-Rentería, Claudia
Luis, Balderrama-Bañares Jorge
Portocarrero-Ortiz, Lesly
Terrones-Lozano, Alejandro
Hernández-Hernández, Alan
Nathal Vera, Edgar
Guinto-Nishimura, Gerardo Yoshiaki
Serna-Soto, Judith de la
Reza-Albarran, Alfredo Adolfo
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-02
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Pheochromocytomas (Pheo) and paragangliomas (PGL) are rare neuroendocrine tumors arising from chromaffin cells of the adrenal medulla and from the extra-adrenal autonomic paraganglia, respectively.
Only 1–3% of head and neck PGL (HNPGL) show elevated catecholamines, and at least 30% of Pheo and PGL (PCPG) are associated with genetic syndromes caused by germline mutations in tumor suppressor genes and proto-oncogenes.
Clinical Case.
A 33-year-old man with a past medical history of resection of an abdominal PGL at the age of eleven underwent a CT scan after a mild traumatic brain injury revealing an incidental brain tumor.
The diagnosis of a functioning PGL was made, and further testing was undertaken with a PET-CT with 68Ga-DOTATATE, SPECT-CT 131-MIBG, and genetic testing.
Discussion and Conclusion.
The usual clinical presentation of functioning PCPG includes paroxistic hypertension, headache, and diaphoresis, sometimes with a suggestive family history in 30–40% of cases.
Only 20% of PGL are located in head and neck, of which only 1–3% will show elevated catecholamines.
Metastatic disease is present in up to 50% of cases, usually associated with a hereditary germline mutation.
However, different phenotypes can be observed depending on such germline mutations.
Genetic testing is important in patients with PCPG since 31% will present a germline mutation.
In this particular patient, an SDHB gene mutation was revealed, which can drastically influence the follow-up plan and the genetic counsel offered.
A multidisciplinary approach is mandatory for every patient presenting with PCPG.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Terrones-Lozano, Alejandro& Hernández-Hernández, Alan& Nathal Vera, Edgar& Guinto-Nishimura, Gerardo Yoshiaki& Luis, Balderrama-Bañares Jorge& Ramírez-Rentería, Claudia…[et al.]. 2020. Current Approach of Functioning Head and Neck Paragangliomas: Case Report of a Young Patient with Multiple Asynchronous Tumors. Case Reports in Endocrinology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147061
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Terrones-Lozano, Alejandro…[et al.]. Current Approach of Functioning Head and Neck Paragangliomas: Case Report of a Young Patient with Multiple Asynchronous Tumors. Case Reports in Endocrinology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1147061
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Terrones-Lozano, Alejandro& Hernández-Hernández, Alan& Nathal Vera, Edgar& Guinto-Nishimura, Gerardo Yoshiaki& Luis, Balderrama-Bañares Jorge& Ramírez-Rentería, Claudia…[et al.]. Current Approach of Functioning Head and Neck Paragangliomas: Case Report of a Young Patient with Multiple Asynchronous Tumors. Case Reports in Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147061
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147061
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر