Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China
المؤلفون المشاركون
Guo, Xiong
Wang, Xi
Ning, Yujie
Zhang, Pan
Yang, Lei
Li, Cheng
Zhou, Rong
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Clinical variables contribute to the severity of Kashin-Beck disease (KBD).
However, it is unclear if there is a correlation between gene expression and clinical variables.
Peripheral blood samples were collected from 100 patients with KBD and 100 healthy controls from KBD-endemic areas to identify differentially expressed genes in KBD.
Correlation analysis and multiple logistic regression analysis were performed using gene expression and clinical parameters.
Immunohistochemistry (IHC) was used to detect the expression of related proteins in articular cartilage tissues.
Thirty-nine differentially expressed genes were identified in patients with KBD.
Nine differentially expressed genes were correlated with the metacarpal length/metacarpal breadth index.
FZD1 was identified as having statistical significance in establishing the regression model of clinical parameters and gene expression.
FZD1 expression levels were remarkably reduced in patients with KBD.
Our results indicate that FZD1 could be involved in the pathological process of phalanges tuberositas and brachydactylia and may provide new insight into the pathogenesis of articular cartilage destruction observed in patients with KBD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xi& Ning, Yujie& Zhang, Pan& Yang, Lei& Li, Cheng& Zhou, Rong…[et al.]. 2019. Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China. Disease Markers،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147081
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xi…[et al.]. Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China. Disease Markers No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1147081
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xi& Ning, Yujie& Zhang, Pan& Yang, Lei& Li, Cheng& Zhou, Rong…[et al.]. Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147081
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147081
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر