Human Epididymis Protein 4 (HE4) Reference Limits in Polish Population of Healthy Women, Pregnant Women, and Women with Benign Ovarian Tumors
المؤلفون المشاركون
Warchoł, Wojciech
Gasiorowska, Emilia
Kluz, Tomasz
Lipski, Dawid
Tykarski, Andrzej
Nowak-Markwitz, Ewa
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
Defining precisely the normal range of HE4 protein is crucial for the proper interpretation of tumor marker results and for a more efficient diagnosis of ovarian malignancy.
The aim of our study was to evaluate a reference limit of HE4 protein in a population to promote and facilitate the common use of HE4 protein assays.
We also tried to identify potential association of HE4 levels with other conditions such as smoking, age, BMI, and creatinine levels.
Methods.
Blood samples were collected from 617 patients divided into three groups: healthy, pregnant, and with benign ovarian tumors.
Serum HE4 concentrations were measured following a standard procedure.
HE4 reference ranges for each group and association of HE4 levels with BMI, creatinine, and smoking were investigated.
Results.
HE4 reference limit for healthy patients equals 85 pmol/l, which becomes 73 pmol/l and 93 pmol/l for pre and postmenopausal subgroups, respectively.
There is a statistically significant correlation between HE4 serum level and smoking (p=0.000001) and there is no correlation with creatinine.
But if we take into account age and smoking, in multivariate analysis, there is a correlation.
For pregnant, the upper limit values of normal HE4 levels are 55 pmol/l (median=40 pmol/l), 80 pmol/l (median=43 pmol/l), and 106 pmol/l (median=53 pmol/l) for the first, second, and third trimesters, respectively.
Conclusions.
HE4 protein value strongly depends on the patient’s age and smoking.
The serum concentration of HE4 marker increases with the duration of pregnancy.
Understanding the normal range of HE4 protein enables the correct interpretation of marker measurements.
This may result in an earlier and more effective diagnosis of ovarian cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gasiorowska, Emilia& Kluz, Tomasz& Lipski, Dawid& Warchoł, Wojciech& Tykarski, Andrzej& Nowak-Markwitz, Ewa. 2019. Human Epididymis Protein 4 (HE4) Reference Limits in Polish Population of Healthy Women, Pregnant Women, and Women with Benign Ovarian Tumors. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147142
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gasiorowska, Emilia…[et al.]. Human Epididymis Protein 4 (HE4) Reference Limits in Polish Population of Healthy Women, Pregnant Women, and Women with Benign Ovarian Tumors. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1147142
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gasiorowska, Emilia& Kluz, Tomasz& Lipski, Dawid& Warchoł, Wojciech& Tykarski, Andrzej& Nowak-Markwitz, Ewa. Human Epididymis Protein 4 (HE4) Reference Limits in Polish Population of Healthy Women, Pregnant Women, and Women with Benign Ovarian Tumors. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147142
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147142
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر