Vitamin D Deficiency Predicts Poor Clinical Outcomes in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy
المؤلفون المشاركون
Merkely, Béla
Boros, András Mihály
Perge, Péter
Zima, Endre
Széplaki, Gábor
Gellér, L.
Osztheimer, I.
Szilágyi, Sz
Tahin, T.
Apor, A.
Nagy, K. V.
Molnár, L.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background and Aims.
Resynchronization therapy (CRT) improves mortality and induces reverse remodeling in heart failure (HF) patients with reduced ejection fraction and wide QRS.
Nonetheless, some patients do not improve despite the optimal medical therapy and right indications for device implantation.
Therefore, finding biomarkers suitable for identification of those patients is crucial.
Vitamin D plays a classic hormonal role in the regulation of bone metabolism and also has physiological functions in wide range of nonskeletal tissues.
Based on recent studies, low levels of vitamin D seem to directly contribute to pathogenesis and worsening of HF.
We planned to assess the role of vitamin D levels on clinical outcomes of HF patients undergoing CRT.
Methods and Results.
We enrolled 136 HF patients undergoing CRT.
Total plasma vitamin D levels were measured at baseline and 6 months later.
Primary endpoint was 5-year all-cause mortality; secondary endpoint was lack of good clinical response, defined as less than 15% increase of left ventricular ejection fraction after six months.
During follow-up, 58 patients reached the primary, and 45 patients reached the secondary endpoint.
Vitamin D levels less than 24.13 ng/mL predicted 5-year mortality (p=0.045) and poor clinical response (p=0.03) after adjusting to all significant baseline predictors.
Conclusion.
Our study showed that vitamin D deficiency has a significant impact in heart failure patients; it is an independent predictor of lack of midterm clinical response and long-term mortality in patients undergoing CRT.
Therefore, monitoring vitamin D status of heart failure patients could be of clinical significance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Perge, Péter& Boros, András Mihály& Gellér, L.& Osztheimer, I.& Szilágyi, Sz& Tahin, T.…[et al.]. 2019. Vitamin D Deficiency Predicts Poor Clinical Outcomes in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147177
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Perge, Péter…[et al.]. Vitamin D Deficiency Predicts Poor Clinical Outcomes in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1147177
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Perge, Péter& Boros, András Mihály& Gellér, L.& Osztheimer, I.& Szilágyi, Sz& Tahin, T.…[et al.]. Vitamin D Deficiency Predicts Poor Clinical Outcomes in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147177
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147177
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر