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Comparison of Performance of Equations for Estimated Glomerular Filtration Rate in Chinese Patients with Biopsy-Proven Diabetic Nephropathy
المؤلفون المشاركون
Wang, Tingli
Zhang, Junlin
Han, Qianqian
Li, Hanyu
Wang, Yiting
Liu, Fang
Teng, Geer
Wu, Yucheng
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The performance of various equations for estimated glomerular filtration rate (eGFR) in patients with diabetes remains controversial.
We aimed to evaluate the performance of equations for eGFR in Chinese patients with diabetic nephropathy (DN).
Methods.
This is a retrospective study included in 308 patients with type 2 diabetes and biopsy-proven DN who were followed up at least one year.
eGFR was calculated using chronic kidney disease epidemiology (CKD-EPI) equations based on serum creatinine (eGFRCKD-EPI-Cr), cystatin C (eGFRCKD-EPI-CysC), and joint equations (eGFRCKD-EPI-Cr-CysC), respectively.
End-stage kidney disease was defined by initiation of renal replacement therapy.
The eGFR concordance between equations was assessed by Bland-Altman plots.
Log-rank and multivariable logistic regression were employed to evaluate the performance of equations.
Results.
Overall, the proportion of patients with eGFR<60 mL/min/1.73m2 was 53%, 70%, and 61% by the equations of eGFRCKD-EPI-Cr, eGFRCKD-EPI-CysC, and eGFRCKD-EPI-Cr-CysC, respectively.
Higher disconcordance was observed between equations when eGFR>60 mL/min/1.73m2.
Compared with eGFRCKD-EPI-Cr, 39% of patients were reclassified (reclassified group) from CKD 1-2 stages to CKD 3-5 stages by eGFRCKD-EPI-CysC and they presented significantly longer diabetic duration, heavier proteinuria, advanced pathological lesions, and poorer kidney outcomes.
Multivariable logistic regression indicated cystatin C was independently associated with advanced glomerular classifications.
Conclusion.
eGFR equations incorporating cystatin C are superior to eGFR based on creatinine alone for detecting kidney injury in the early stage.
The independent association between cystatin C and glomerular classifications might contribute to it.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yiting& Zhang, Junlin& Teng, Geer& Wu, Yucheng& Han, Qianqian& Li, Hanyu…[et al.]. 2019. Comparison of Performance of Equations for Estimated Glomerular Filtration Rate in Chinese Patients with Biopsy-Proven Diabetic Nephropathy. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147186
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yiting…[et al.]. Comparison of Performance of Equations for Estimated Glomerular Filtration Rate in Chinese Patients with Biopsy-Proven Diabetic Nephropathy. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1147186
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yiting& Zhang, Junlin& Teng, Geer& Wu, Yucheng& Han, Qianqian& Li, Hanyu…[et al.]. Comparison of Performance of Equations for Estimated Glomerular Filtration Rate in Chinese Patients with Biopsy-Proven Diabetic Nephropathy. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147186
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147186
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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