Competitive Endogenous RNA Network Construction and Comparison of Lung Squamous Cell Carcinoma in Smokers and Nonsmokers
المؤلفون المشاركون
Wang, Xue
Yao, Yan
Zhang, Tingting
Qi, Lingyu
Liu, Ruijuan
Liu, Gongxi
Li, Jie
Li, Jia
Sun, Changgang
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-04
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
Lung squamous cell carcinoma (LUSC) is a subtype of highly malignant lung cancer with poor prognosis, for which smoking is the main risk factor.
However, the underlying genetic and molecular mechanisms of smoking-related LUSC remain largely unknown.
Methods.
We mined existing LUSC-related mRNA, miRNA, and lncRNA transcriptome data and corresponding clinical data from The Cancer Genome Atlas (TCGA) database and divided them into smoking and nonsmoking groups, followed by differential expression analysis.
Functional enrichment analysis of the unique differentially expressed mRNAs of the two groups was performed using the DAVID database.
Subsequently, the lncRNA-miRNA-mRNA competing endogenous RNA (ceRNA) network of LUSC in smoking and nonsmoking groups was constructed.
Finally, survival analyses were performed to determine the effects of differentially expressed lncRNAs/mRNAs/miRNAs that were involved in the ceRNA network on overall survival and to discover the hub genes.
Results.
A total of 1696 lncRNAs, 125 miRNAs, and 3246 mRNAs and 1784 lncRNAs, 96 miRNAs, and 3229 mRNAs with differentially expressed profiles were identified in the smoking and nonsmoking groups, respectively.
The ceRNA network and survival analysis revealed four lncRNAs (LINC00466, DLX6-AS1, LINC00261, and AGBL1), one miRNA (hsa-mir-210), and two mRNAs (CITED2 and ENPP4), with the potential as biomarkers for smoking-related LUSC diagnosis and prognosis.
Conclusion.
Taken together, our research has identified the differences in the ceRNA regulatory networks between smoking and nonsmoking LUSC, which could lay the foundation for future clinical research.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yao, Yan& Zhang, Tingting& Qi, Lingyu& Liu, Ruijuan& Liu, Gongxi& Wang, Xue…[et al.]. 2019. Competitive Endogenous RNA Network Construction and Comparison of Lung Squamous Cell Carcinoma in Smokers and Nonsmokers. Disease Markers،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1147362
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yao, Yan…[et al.]. Competitive Endogenous RNA Network Construction and Comparison of Lung Squamous Cell Carcinoma in Smokers and Nonsmokers. Disease Markers No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1147362
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yao, Yan& Zhang, Tingting& Qi, Lingyu& Liu, Ruijuan& Liu, Gongxi& Wang, Xue…[et al.]. Competitive Endogenous RNA Network Construction and Comparison of Lung Squamous Cell Carcinoma in Smokers and Nonsmokers. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1147362
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147362
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر