The Value of lncRNA GHET1 as a Prognostic Factor for Survival of Chinese Cancer Outcome: A Meta-Analysis
المؤلفون المشاركون
Song, Junying
Chen, Xian
Tian, Qingwu
Lun, Limin
Wang, Qing
Wang, Hongwei
Li, Xiaopeng
Liu, Zhongqiang
Tian, Liyuan
Jing, Xuran
Zhang, Yunyuan
Tian, Runhua
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
There is increasing evidence that high expression levels of the gastric carcinoma highly expressed transcript 1 (GHET1), a long noncoding RNA (lncRNA), are associated with cancer prognosis and may be used as a valuable biomarker for cancer patients.
The purpose of this meta-analysis was to analyze existing data to reveal potential clinical applications of GHET1 for cancer prognosis and tumor progression.
All of these studies included in this meta-analysis were collected through a variety of retrieval strategies; and the enrolled articles were qualified via the meta-analysis of enrolled studies in epidemiology (MOOSE) and the preferred reporting items for systematic reviews and meta-analyses (PRISMA) checklists.
Materials and Methods.
The literature collection was performed by a comprehensive search through electronic databases for studies published on or before March 10, 2019.
These included the Cochrane library, PubMed, Embase, Web of Science, Springer, Science Direct, and three Chinese databases: CNKI, Weipu, and Wanfang.
Seven studies that met the specified criteria were analyzed in the present research.
Results.
The combined results indicate that an elevated GHET1 expression level is significantly associated with poor overall survival (OS) (HR=2.40, 95% CI: 1.87–3.08, p<0.001) and tumor progression (III/IV vs.
I/II: HR=1.80, 95% CI: 1.48–2.18, p<0.001) in multiple cancers.
The elevated GHET1 expression was also associated with lymph node metastasis (LNM) (HR=2.44, 95% CI: 1.86–3.20, p<0.001) in Chinese cancer patients.
Conclusions.
The present findings indicate that an increased GHET1 expression level is associated with poor OS, tumor progression, and LNM in patients with multiple tumors and may serve as a useful prognostic biomarker in Chinese cancer patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Junying& Chen, Xian& Tian, Qingwu& Lun, Limin& Wang, Qing& Wang, Hongwei…[et al.]. 2019. The Value of lncRNA GHET1 as a Prognostic Factor for Survival of Chinese Cancer Outcome: A Meta-Analysis. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147474
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Junying…[et al.]. The Value of lncRNA GHET1 as a Prognostic Factor for Survival of Chinese Cancer Outcome: A Meta-Analysis. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1147474
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Junying& Chen, Xian& Tian, Qingwu& Lun, Limin& Wang, Qing& Wang, Hongwei…[et al.]. The Value of lncRNA GHET1 as a Prognostic Factor for Survival of Chinese Cancer Outcome: A Meta-Analysis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1147474
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147474
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر