Overexpression of UDP-Glucose 4-Epimerase Is Associated with Differentiation Grade of Gastric Cancer
المؤلفون المشاركون
Pitta, Ivan da Rocha
de Melo Rego, Moacyr Jesus Barreto
Cordeiro, Marina Ferraz
de Souza, Maria de Fátima Deodato
da Silva Filho, Antônio Felix
de Barros Albuquerque, Amanda Pinheiro
Quirino, Michael Williams Leal
de Souza Albuquerque, Mário Sérgio
Martins, Mário Rino
Lucena-Araujo, Antônio Roberto
Pitta, Maira Galdino da Rocha
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-20
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The UDP-glucose 4-epimerase (GALE) is a glycosyltransferase, which acts on protein and lipid glycosylation in normal and neoplastic cells.
This study is aimed at investigating the differential tissue expression of GALE and its possible association with clinical-pathological parameters and the outcome of gastric adenocarcinoma patients.
Seventy-one patients were evaluated in relation to GALE expression by immunohistochemistry.
Our results showed that 48 (67.6%) patients were GALE positive and 23 (32.4%) negative.
Positive staining was present on well-differentiated and moderate-differentiated histological grade of gastric adenocarcinomas (p<0.0001).
There was no significant association with outcome parameters (p>0.05).
Besides that, our results corroborated with the validation cohort analysis, where the expression of GALE mRNA was also associated with the histological grade (p<0.001).
These results suggest a possible use of this enzyme as a biomarker for well and moderately differentiated tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Souza, Maria de Fátima Deodato& da Silva Filho, Antônio Felix& de Barros Albuquerque, Amanda Pinheiro& Quirino, Michael Williams Leal& de Souza Albuquerque, Mário Sérgio& Cordeiro, Marina Ferraz…[et al.]. 2019. Overexpression of UDP-Glucose 4-Epimerase Is Associated with Differentiation Grade of Gastric Cancer. Disease Markers،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1147574
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Souza, Maria de Fátima Deodato…[et al.]. Overexpression of UDP-Glucose 4-Epimerase Is Associated with Differentiation Grade of Gastric Cancer. Disease Markers No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1147574
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Souza, Maria de Fátima Deodato& da Silva Filho, Antônio Felix& de Barros Albuquerque, Amanda Pinheiro& Quirino, Michael Williams Leal& de Souza Albuquerque, Mário Sérgio& Cordeiro, Marina Ferraz…[et al.]. Overexpression of UDP-Glucose 4-Epimerase Is Associated with Differentiation Grade of Gastric Cancer. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1147574
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147574
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر