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Are All Mutations the Same? A Rare Case Report of Coexisting Mutually Exclusive KRAS and BRAF Mutations in a Patient with Metastatic Colon Adenocarcinoma
المؤلفون المشاركون
Vittal, Anusha
Middinti, Akshay
Kasi Loknath Kumar, Anup
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-24
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
29-year-old Hispanic woman presented to the clinic with complaints of abdominal pain, nausea, fatigue, and constipation.
Laboratory tests indicated the presence of iron deficiency anemia and transaminitis.
Imaging evaluation revealed marked hepatomegaly with multiple hepatic metastases and pelvic lymphadenopathy.
Biopsy of the hepatic lesions showed adenocarcinoma positive for pan-cytokeratin, CMA5.2, villin, and CDX2.
She was positive for tumor markers CA 19-9, CA-125, and CEA.
Upon further evaluation, she was found to have colorectal cancer positive for KRAS and BRAF mutations.
Unfortunately, her disease progressed rapidly and she expired within 3 months from the time of her first diagnosis.
KRAS and BRAF mutations are rare enough to be considered virtually mutually exclusive but coexistent mutations appear to be a distinct molecular and clinical subset with aggressive course of illness, which is in dire need of new treatment strategies.
Panitumumab and Cetuximab are approved for patients with wild type KRAS CRC.
Vemurafenib is a potent inhibitor of the kinase domain in mutant BRAF and its use in BRAF mutated colon cancer remains to be well established.
Our report highlights the need to obtain tissue samples from these patients for analysis and to evaluate the benefit of Vemurafenib in colorectal cancers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vittal, Anusha& Middinti, Akshay& Kasi Loknath Kumar, Anup. 2017. Are All Mutations the Same? A Rare Case Report of Coexisting Mutually Exclusive KRAS and BRAF Mutations in a Patient with Metastatic Colon Adenocarcinoma. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147630
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vittal, Anusha…[et al.]. Are All Mutations the Same? A Rare Case Report of Coexisting Mutually Exclusive KRAS and BRAF Mutations in a Patient with Metastatic Colon Adenocarcinoma. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1147630
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vittal, Anusha& Middinti, Akshay& Kasi Loknath Kumar, Anup. Are All Mutations the Same? A Rare Case Report of Coexisting Mutually Exclusive KRAS and BRAF Mutations in a Patient with Metastatic Colon Adenocarcinoma. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147630
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147630
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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