TFAP4 Promotes Hepatocellular Carcinoma Invasion and Metastasis via Activating the PI3KAKT Signaling Pathway
المؤلفون المشاركون
Chang, Boyang
Huang, Tao
Chen, Qi-Feng
Shen, Lu-Jun
Li, Wang
Wu, Pei-Hong
Fan, Wei-Jun
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-10
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Transcription factor activating enhancer binding protein 4 (TFAP4) is established as a regulator of human cancer genesis and progression.
Overexpression of TFAP4 indicates poor prognosis in various malignancies.
The current study was performed to quantify TFAP4 expression as well as to further determine its potential prognostic value and functional role in patients with hepatocellular carcinoma (HCC).
We identified that the expression of TFAP4 mRNA in 369 tumor tissues was higher than that in 160 normal liver tissues.
Upregulated TFAP4 expressions were discovered in HCC cell lines compared to the healthy liver cell line, and similarly, the levels of TFAP4 were higher in tumor tissues than its expression in paratumor tissues.
High mRNA and protein expression of TFAP4 was associated with worse overall survival (OS) and disease-free survival (DFS).
Additionally, TFAP4 expression emerged as a risk factor independently affecting both OS and DFS of HCC patients.
Functional studies demonstrated that TFAP4 increased HCC cell migration and invasion.
Further investigations found that TFAP4 promotes invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) and regulating MMP-9 expression via activating the PI3K/AKT signaling pathway in HCC.
In conclusion, our study demonstrated that TFAP4 is a valuable prognostic biomarker in determining the likelihood of tumor metastasis and recurrence, as well as the long-term survival rates of HCC patients.
Exploring the regulatory mechanism of TFAP4 will also contribute to the development of new prevention and treatment strategies for HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Tao& Chen, Qi-Feng& Chang, Boyang& Shen, Lu-Jun& Li, Wang& Wu, Pei-Hong…[et al.]. 2019. TFAP4 Promotes Hepatocellular Carcinoma Invasion and Metastasis via Activating the PI3KAKT Signaling Pathway. Disease Markers،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1147645
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Tao…[et al.]. TFAP4 Promotes Hepatocellular Carcinoma Invasion and Metastasis via Activating the PI3KAKT Signaling Pathway. Disease Markers No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1147645
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Tao& Chen, Qi-Feng& Chang, Boyang& Shen, Lu-Jun& Li, Wang& Wu, Pei-Hong…[et al.]. TFAP4 Promotes Hepatocellular Carcinoma Invasion and Metastasis via Activating the PI3KAKT Signaling Pathway. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1147645
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147645
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر