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Arsenic Trioxide Treatment during Pregnancy for Acute Promyelocytic Leukemia in a 22-Year-Old Woman
المؤلفون المشاركون
Mottet, Nicolas
Cochet, Claire
Simonet, Marion
Cattin, Julie
Metz, Jean-Patrick
Berceanu, Ana
Deconinck, Eric
Daguindau, Etienne
Schillinger, Françoise
Fenaux, Pierre
Desbrosses, Yohan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-11
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Acute leukemia during pregnancy is rare (1 for 100000 pregnancies).
The association of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is known as the best therapy in standard-risk acute promyelocytic leukemia (APL).
We describe the first case of a pregnancy with ATRA and ATO reported in the literature.
In March 2018 at the University Hospital of Besançon, a 22-year-old woman was diagnosed with APL at 14 weeks of gestation (WG).
She received a total of 2160 mg of ATRA and 930 mg of ATO between 14 and 35 WG.
The mother’s cytological remission was very fast.
No maternal or fetal complications occurred during pregnancy.
The pediatrics outcomes were good.
Many case reports about ATRA exposure during the second and third trimesters report no serious adverse effect for pregnancy.
ATO is teratogenic, genotoxic, and carcinogenic and passes through the placenta.
Fetal exposure seems to be associated with bad pregnancy outcomes (preterm delivery, decreased birth weight, and fetal loss) and with lung diseases in young adults.
No clinical trial is obviously possible, and the only data available are environmental exposure or animal studies.
This case report may help medical teams to make hard decision for a treatment of APL during pregnancy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cochet, Claire& Simonet, Marion& Cattin, Julie& Metz, Jean-Patrick& Berceanu, Ana& Deconinck, Eric…[et al.]. 2020. Arsenic Trioxide Treatment during Pregnancy for Acute Promyelocytic Leukemia in a 22-Year-Old Woman. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147646
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cochet, Claire…[et al.]. Arsenic Trioxide Treatment during Pregnancy for Acute Promyelocytic Leukemia in a 22-Year-Old Woman. Case Reports in Hematology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1147646
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cochet, Claire& Simonet, Marion& Cattin, Julie& Metz, Jean-Patrick& Berceanu, Ana& Deconinck, Eric…[et al.]. Arsenic Trioxide Treatment during Pregnancy for Acute Promyelocytic Leukemia in a 22-Year-Old Woman. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147646
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147646
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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