Myeloid Disease with the CSF3R T618I Mutation after CLL
المؤلفون المشاركون
Couto, Maria Eduarda
Bizarro, Susana
Sousa, Domingos
Oliveira, Isabel
Martins, Gabriela
Teixeira, Manuel R.
Mariz, Mário
Domingues, Nelson
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-21
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Chronic lymphocytic leukemia (CLL) is frequently an indolent diagnosis, with most of the patients being under surveillance for long time.
There is an increased risk of a second neoplasia in CLL, rarely hematological (in the myeloid lineage is even rarer).
A 58-year-old male was diagnosed with CLL in 2012, remaining in regular surveillance until 2014.
Then, the CLL progressed, and 6 cycles of rituximab, fludarabine, and cyclophosphamide were prescribed with partial response.
He remained in surveillance and suffered 2 episodes of autoimmune hemolytic anemia until 2019.
Then, the hemolytic anemia relapsed and a neutrophilia became evident (progressing slowly), as well as a thrombocytopenia and splenomegaly without adenopathy were found.
The bone marrow aspirate showed a chronic myeloproliferative disease without dysplasia.
A peripheral blood search for the CSF3R mutation (T618I) was positive, also suggesting Chronic Neutrophilic Leukemia (CNL).
For a discrete monocytosis, a chronic myelomonocytic leukemia (CMML) was also considered.
Hydroxyurea was then prescribed.
The T618I CSF3R mutation is highly suggestive of CNL (being diagnostic criteria for CNL); however, this case may also suggest CMML as a possible diagnosis (there are other mutations in the CSF3R gene described for CMML, but not the T618I, which is highly exclusive of CNL according to the literature).
To our knowledge, this is the first report of a possible CNL in a CLL patient (the opposite was already described in 1998).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Couto, Maria Eduarda& Bizarro, Susana& Sousa, Domingos& Domingues, Nelson& Oliveira, Isabel& Martins, Gabriela…[et al.]. 2020. Myeloid Disease with the CSF3R T618I Mutation after CLL. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147706
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Couto, Maria Eduarda…[et al.]. Myeloid Disease with the CSF3R T618I Mutation after CLL. Case Reports in Hematology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1147706
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Couto, Maria Eduarda& Bizarro, Susana& Sousa, Domingos& Domingues, Nelson& Oliveira, Isabel& Martins, Gabriela…[et al.]. Myeloid Disease with the CSF3R T618I Mutation after CLL. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147706
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147706
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر