Pancreatic Adenocarcinoma Producing Parathyroid Hormone-Related Protein

الملخص EN

A 48-year-old woman presented to our hospital with a 1-year history of a continuous high fever.

She was diagnosed with metastatic pancreatic adenocarcinoma accompanied by leukocytosis without infection.

Her serum concentration of granulocyte colony-stimulating factor was highly elevated.

Forty-five days after initiating chemotherapy, she was readmitted because of a neuropsychiatric disturbance and hypercalcemia.

Her serum concentration of parathyroid hormone-related protein (PTH-rP) was elevated.

A pretreatment biopsy specimen showed strong cytoplasmic immunoreactivity to anti-PTH-rP antibody, suggesting that overproduction of PTH-rP accounted for the hypercalcemia.

Although the patient regained consciousness after treatment, she died of progressive disease 60 days after chemotherapy.