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Metabolic Disturbances Identified in Plasma Samples from ST-Segment Elevation Myocardial Infarction Patients
المؤلفون المشاركون
Resende, Rodrigo R.
Goulart, Vânia A. M.
Sandrim, Valéria C.
Pinto, Mauro C. X.
Santos, Anderson Kenedy
Batista, Josimar Marques
Cameron, Luiz Cláudio
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
ST-segment elevation myocardial infarction (STEMI) is the most severe form of myocardial infarction (MI) and the main contributor to morbidity and mortality caused by MI worldwide.
Frequently, STEMI is caused by complete and persistent occlusion of a coronary artery by a blood clot, which promotes heart damage.
STEMI impairment triggers changes in gene transcription, protein expression, and metabolite concentrations, which grants a biosignature to the heart dysfunction.
There is a major interest in identifying novel biomarkers that could improve the diagnosis of STEMI.
In this study, the phenotypic characterization of STEMI patients (n=15) and healthy individuals (n=19) was performed, using a target metabolomics approach.
Plasma samples were analyzed by UPLC-MS/MS (ultra-high-performance liquid chromatography-tandem mass spectrometry) and FIA-MS (MS-based flow injection analysis).
The goal was to identify novel plasma biomarkers and metabolic signatures underlying STEMI.
Concentrations of phosphatidylcholines, lysophosphatidylcholines, sphingomyelins, and biogenic amines were altered in STEMI patients in relation to healthy subjects.
Also, after multivariate analysis, it was possible to identify alterations in the glycerophospholipids, alpha-linolenic acid, and sphingolipid metabolisms in STEMI patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Goulart, Vânia A. M.& Santos, Anderson Kenedy& Sandrim, Valéria C.& Batista, Josimar Marques& Pinto, Mauro C. X.& Cameron, Luiz Cláudio…[et al.]. 2019. Metabolic Disturbances Identified in Plasma Samples from ST-Segment Elevation Myocardial Infarction Patients. Disease Markers،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147786
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Goulart, Vânia A. M.…[et al.]. Metabolic Disturbances Identified in Plasma Samples from ST-Segment Elevation Myocardial Infarction Patients. Disease Markers No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1147786
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Goulart, Vânia A. M.& Santos, Anderson Kenedy& Sandrim, Valéria C.& Batista, Josimar Marques& Pinto, Mauro C. X.& Cameron, Luiz Cláudio…[et al.]. Metabolic Disturbances Identified in Plasma Samples from ST-Segment Elevation Myocardial Infarction Patients. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147786
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147786
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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