T Cell Histiocyte Rich Large B Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: An Uncommon Presentation of a Rare Disease
المؤلفون المشاركون
Ibrahim, Uroosa
Saqib, Amina
Hussein, Shafinaz
Garcia, Gwenalyn
Dai, Qun
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-21
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
T cell histiocyte rich large B cell lymphoma (THRLBCL) is a rare subtype of non-Hodgkin’s lymphoma characterized by malignant B cells with reactive T lymphocytes.
The pathophysiology is thought to involve cytokine-mediated evasion of T cell immune response by malignant B cells.
It usually presents at an advanced stage with extranodal involvement.
An extremely unusual manifestation of the disease is hemophagocytic lymphohistiocytosis (HLH) which is a hyperinflammatory disorder.
We present a case of a 43-year-old male who presented with recurrent fever and recent radiologic imaging showing splenomegaly and right inguinal lymphadenopathy.
On presentation, he had a fever of 105°F.
Laboratory work-up was consistent with pancytopenia, elevated lactate dehydrogenase, elevated D-dimer, and a ferritin of 24,247 ng/mL.
The patient was started on steroid therapy.
An excisional biopsy of the right inguinal lymph node was consistent with a diagnosis of THRLBCL and the patient subsequently received six cycles of chemotherapy with R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) after which a PET-CT scan showed no evidence of biologically active disease and ferritin was down to 822 ng/mL.
We discuss the clinical manifestations and diagnostic and therapeutic considerations of this rare disease along with a review of reported cases in the literature.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ibrahim, Uroosa& Garcia, Gwenalyn& Saqib, Amina& Hussein, Shafinaz& Dai, Qun. 2017. T Cell Histiocyte Rich Large B Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: An Uncommon Presentation of a Rare Disease. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1147807
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ibrahim, Uroosa…[et al.]. T Cell Histiocyte Rich Large B Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: An Uncommon Presentation of a Rare Disease. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1147807
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ibrahim, Uroosa& Garcia, Gwenalyn& Saqib, Amina& Hussein, Shafinaz& Dai, Qun. T Cell Histiocyte Rich Large B Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: An Uncommon Presentation of a Rare Disease. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1147807
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147807
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر