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Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population
المؤلفون المشاركون
Zhou, Bin
Li, Qin
Li, Kai
Su, Min
Huang, Xingming
Shen, Can
Zhang, Yan
Song, Yaping
Wang, Wei
Wang, Yan Yun
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Epithelial ovarian cancer (EOC) is highly lethal worldwide.
Factors involved in the inflammation and hormone-associated signaling pathway play vital roles in EOC carcinogenesis.
The transforming growth factor-β- (TGF-β-) activated kinase 1 (MAP3K7) binding protein 2 (TAB2), mediating convergence of inflammatory and estrogen, may be implicated in EOC.
The present study is aimed at exploring the association between the TAB2 gene polymorphisms and EOC.
Methods.
Three single nucleotide polymorphisms (SNPs) (rs237028, rs521845, and rs652921) of TAB2 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 221 patients and 252 healthy controls.
Associations between SNPs and clinical characteristics were performed either with the χ2 test or with Fisher’s exact test.
The Kaplan-Meier method and Cox proportional hazard models were used to detect associations between genotypes and overall survival.
Results.
The rs237028 polymorphism was significantly associated with an increased risk of EOC with an allelic genetic model (A vs.
G; OR=1.45; 95%CI=1.07–1.96; P=0.016), dominant genetic model (AA vs.
AG-GG; OR=1.66; CI 1.14–2.41; P=0.008), and overdominant genetic model (AA-GG vs.
AG; OR=1.60; CI 1.08–2.36; P=0.017).
However, no significant association was observed between rs237028 polymorphism and overall survival.
Conclusions.
Our study indicated that the rs237028 polymorphism in the TAB2 gene was associated with EOC susceptibility and the TAB2 gene might contribute to the initiation of EOC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Xingming& Shen, Can& Zhang, Yan& Li, Qin& Li, Kai& Wang, Yan Yun…[et al.]. 2019. Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population. Disease Markers،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147815
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Xingming…[et al.]. Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population. Disease Markers No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1147815
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Xingming& Shen, Can& Zhang, Yan& Li, Qin& Li, Kai& Wang, Yan Yun…[et al.]. Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147815
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147815
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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