Complete Response after Treatment with Neoadjuvant Chemoradiation with Prolonged Chemotherapy for Locally Advanced, Unresectable Adenocarcinoma of the Pancreas
المؤلفون المشاركون
Bowne, Wilbur B.
Pompa, Tiffany A.
Morano, William F.
Jeurkar, Chetan
Li, Hui
Soundararajan, Suganthi
Poli, Jaganmohan
Styler, Michael
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Surgery is the only chance for cure in pancreatic ductal adenocarcinoma.
In unresectable, locally advanced pancreatic cancer (LAPC), the National Comprehensive Cancer Network (NCCN) suggests chemotherapy and consideration for radiation in cases of unresectable LAPC.
Here we present a rare case of unresectable LAPC with a complete histopathological response after chemoradiation followed by surgical resection.
A 54-year-old female presented to our clinic in December 2013 with complaints of abdominal pain and 30-pound weight loss.
An MRI demonstrated a mass in the pancreatic body measuring 6.2×3.2 cm; biopsy revealed proven ductal adenocarcinoma.
Due to splenic vein/artery and contiguous celiac artery encasement, she was deemed surgically unresectable.
She was started on FOLFIRINOX therapy (three cycles), intensity modulated radiation to a dose of 54 Gy in 30 fractions concurrent with capecitabine, followed by FOLFIRI, and finally XELIRI.
After 8 cycles of ongoing XELIRI completed in March 2015, restaging showed a remarkable decrease in tumor size, along with PET-CT revealing no FDG-avid uptake.
She was reevaluated by surgery and taken for definitive resection.
Histopathological evaluation demonstrated a complete R0 resection and no residual tumor.
Based on this patient and literature review, this strategy demonstrates potential efficacy of neoadjuvant chemoradiation with prolonged chemotherapy, followed by surgery, which may improve outcomes in patients deemed previously unresectable.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pompa, Tiffany A.& Morano, William F.& Jeurkar, Chetan& Li, Hui& Soundararajan, Suganthi& Poli, Jaganmohan…[et al.]. 2017. Complete Response after Treatment with Neoadjuvant Chemoradiation with Prolonged Chemotherapy for Locally Advanced, Unresectable Adenocarcinoma of the Pancreas. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1147848
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pompa, Tiffany A.…[et al.]. Complete Response after Treatment with Neoadjuvant Chemoradiation with Prolonged Chemotherapy for Locally Advanced, Unresectable Adenocarcinoma of the Pancreas. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1147848
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pompa, Tiffany A.& Morano, William F.& Jeurkar, Chetan& Li, Hui& Soundararajan, Suganthi& Poli, Jaganmohan…[et al.]. Complete Response after Treatment with Neoadjuvant Chemoradiation with Prolonged Chemotherapy for Locally Advanced, Unresectable Adenocarcinoma of the Pancreas. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1147848
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147848
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر